Polynucleotide

Details Polynucleotide Polynucleotide

2008-09-22

2011-11-15

Ketter, Jim (Department: 1636)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

C435S091500, C435S091410, C435S320100, C536S024100

Reexamination Certificate

active

08058028

ABSTRACT:
The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) which is not derived from 13. The polynucleotide of any one of claims1to7, wherein the UCOE comprises the sequence of FIG.20between nucleotides 1 to 7627 or a functional homologue or fragment thereof an LCR. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector, use of the polynucleoticle, vector or host cell in therapy and in an assay, and a method of identifying UCOEs. The UCOE opens chromatin or maintains chromatin in an open state and facilitates reproducible expression of an operably-linked gene in cells of at least two different tissue types.

REFERENCES:
patent: 6881556 (2005-04-01), Antoniou et al.
patent: 6949361 (2005-09-01), Antoniou et al.
patent: 7812148 (2010-10-01), Crombie et al.

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