Polynucleotide

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Reexamination Certificate

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C536S024330

Reexamination Certificate

active

07544786

ABSTRACT:
A polynucleotide consisting of the base sequence of SEQ ID NO: 2, or a complementary strand thereto, wherein the X is one of the group being defined by the bases A, C or T. A primer and a probe specific for that polynucleotide, wherein the primer and/or probe contains at the least 10 consecutive nucleotides, and finally use of the probe for proving parkinsonism inheritance.

REFERENCES:
patent: 6420547 (2002-07-01), Maiti et al.
patent: WO 02/081627 (2002-10-01), None
patent: WO 2006/068492 (2006-06-01), None
Zimprich et al., [online], 2004, [retrieved on Nov. 26, 2007]. Retrieved from the Internet:< URL: http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nuccore&id=55740397>, pp. 1-5.
GenBank Accession No. AY792511 dated Nov. 15, 2004, 5 pages.
Bonifati et al., “Mutations in theDJ-IGene Associated with Autosomal Recessive Early-Onset Parkinsonism,”Science, 2003, 299:256-259.
Bosgraaf and Van Haastert, “Roc, a Ras/GTPase domain in complex proteins,”Biochim. Biophys. Acta, 2003, 1643:5-10.
Chartier-Harlin et al., “α-synuclein locus duplication as a cause of familial Parkinson's disease,”Lancet, 2004, 364:1167-1169.
Davies et al., “Mutations of theBRAFgene in human cancer,”Nature, 2002, 417:949-954.
de Rijk et al., “Prevalence of Parkinson's disease in the elderly: the Rotterdam Study,”Neurology, 1995, 45:2143-2146.
Dibb et al., “Switching on kinases: oncogenic activation of BRAF and the PDGFR family.”Nat. Rev. Cancer, 2004, 4:718-727.
Farrer et al., “Comparison of Kindreds with Parkinsonism and α-Synuclein Genomic Multiplications,”Ann. Neurol., 2004, 55:174-179.
Forno, “Neuropathology of Parkinson's Disease,”J. Neuropathol. Exp. Neurol., 1996, 55(3):259-272.
Funayama et al., “A New Locus for Parkinson'Disease (PARK8) Maps to Chromosome 12p11.2-q13.1,”Ann. Neurol., 2002, 51:296-301.
Gelb et al., “Diagnostic Criteria for Parkinson Disease,”Arch. Neurol., 1999, 56:33-39.
Hughes et al., “Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases,”J. Neurol. Neurosurg. Psychiatry, 1992, 55:181-184.
Huse and Kuriyan, “The Conformational Plasticity of Protein Kinases,”Cell, 2002, 109:275-282.
Kitada et al., “Mutations in theparkingene cause autosomal recessive juvenile parkinsonism,”Nature, 1998, 392:605-608.
Kong and Cox, “Allele-Sharing Models: LOD Scores and Accurate Linkage Tests,”Am. J. Hum. Genet., 1997, 61:1179-1188.
Krüger et al., “Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease,”Nat. Genet., 1998, 18:106-108.
Lander and Kruglyak, “Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results,”Nat. Genet., 1995, 11:241-247.
Lang and Lazano, “Parkinson's Disease. First of Two Parts,”New Engl. J. Med., 1998, 339:1044-1053.
Mata et al., “Parkin genetics: one model for Parkinson's disease,”Hum. Mol. Genet., 2004, 13:R127-R133.
Paisáan-Ruiz et al., “Cloning of the Gene Containing Mutations that CausePARK8-Linked Parkinson's Disease,”Neuron, 2004, 44:595-600.
Pals et al., “α-Synuclein Promoter Confers Susceptibility to Parkinson's Disease,”Ann. Neurol., 2004, 56:591-595.
Polymeropoulos et al., “Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease,”Science, 1997, 276:2045-2047.
Simon et al., “‘Nature versus murture’ and incompletely penetrant mutations,”J. Neurol. Neurosurg. Psychiatry, 2002, 72:686-688.
Singleton et al., “α-Synuclein Locus Triplication Causes Parkinson's Disease,”Science, 2003, 302:841.
Slatkin and Rannala, “Estimating allele age,”Annu. Rev. Genomics Hum. Genet., 2000, 1:225-249.
Spillantini et al., “α-Synuclein in Lewy bodies,”Nature, 1997, 388:839-840.
Tanner et al., “Parkinson Disease in Twins: An Etiologic Study,”JAMA, 1999, 281(4):341-346.
Valente et al., “Hereditary Early-Onset Parkinson's Disease Caused by Mutations inPINK1, ”Science, 2004, 304:1158-1160.
Vila and Przedborski, “Genetic clues to the pathogenesis of Parkinson's disease,”Nat. Med., 2004, 10 Suppl:S58-S62.
Wirdefeldt et al. “No evidence for heritability of Parkinson disease in Swedish twins,”Neurology, 2004, 63:305-311.
Zarranz et al., “The New Mutation, E46K, of α-Synuclein Causes Parkinson and Lewy Body Dementia,”Ann. Neurol, 2004, 55:164-173.
Zimprich et al., “Mutations inLRRK2Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology,”Neuron, 2004, 44:601-607.
Zimprich et al., “The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval,”Am. J. Hum. Genet., 2004, 74:11-19.

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