Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2005-12-19
2009-06-09
Hama, Joanne (Department: 1632)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S024330
Reexamination Certificate
active
07544786
ABSTRACT:
A polynucleotide consisting of the base sequence of SEQ ID NO: 2, or a complementary strand thereto, wherein the X is one of the group being defined by the bases A, C or T. A primer and a probe specific for that polynucleotide, wherein the primer and/or probe contains at the least 10 consecutive nucleotides, and finally use of the probe for proving parkinsonism inheritance.
REFERENCES:
patent: 6420547 (2002-07-01), Maiti et al.
patent: WO 02/081627 (2002-10-01), None
patent: WO 2006/068492 (2006-06-01), None
Zimprich et al., [online], 2004, [retrieved on Nov. 26, 2007]. Retrieved from the Internet:< URL: http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?db=nuccore&id=55740397>, pp. 1-5.
GenBank Accession No. AY792511 dated Nov. 15, 2004, 5 pages.
Bonifati et al., “Mutations in theDJ-IGene Associated with Autosomal Recessive Early-Onset Parkinsonism,”Science, 2003, 299:256-259.
Bosgraaf and Van Haastert, “Roc, a Ras/GTPase domain in complex proteins,”Biochim. Biophys. Acta, 2003, 1643:5-10.
Chartier-Harlin et al., “α-synuclein locus duplication as a cause of familial Parkinson's disease,”Lancet, 2004, 364:1167-1169.
Davies et al., “Mutations of theBRAFgene in human cancer,”Nature, 2002, 417:949-954.
de Rijk et al., “Prevalence of Parkinson's disease in the elderly: the Rotterdam Study,”Neurology, 1995, 45:2143-2146.
Dibb et al., “Switching on kinases: oncogenic activation of BRAF and the PDGFR family.”Nat. Rev. Cancer, 2004, 4:718-727.
Farrer et al., “Comparison of Kindreds with Parkinsonism and α-Synuclein Genomic Multiplications,”Ann. Neurol., 2004, 55:174-179.
Forno, “Neuropathology of Parkinson's Disease,”J. Neuropathol. Exp. Neurol., 1996, 55(3):259-272.
Funayama et al., “A New Locus for Parkinson'Disease (PARK8) Maps to Chromosome 12p11.2-q13.1,”Ann. Neurol., 2002, 51:296-301.
Gelb et al., “Diagnostic Criteria for Parkinson Disease,”Arch. Neurol., 1999, 56:33-39.
Hughes et al., “Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases,”J. Neurol. Neurosurg. Psychiatry, 1992, 55:181-184.
Huse and Kuriyan, “The Conformational Plasticity of Protein Kinases,”Cell, 2002, 109:275-282.
Kitada et al., “Mutations in theparkingene cause autosomal recessive juvenile parkinsonism,”Nature, 1998, 392:605-608.
Kong and Cox, “Allele-Sharing Models: LOD Scores and Accurate Linkage Tests,”Am. J. Hum. Genet., 1997, 61:1179-1188.
Krüger et al., “Ala30Pro mutation in the gene encoding α-synuclein in Parkinson's disease,”Nat. Genet., 1998, 18:106-108.
Lander and Kruglyak, “Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results,”Nat. Genet., 1995, 11:241-247.
Lang and Lazano, “Parkinson's Disease. First of Two Parts,”New Engl. J. Med., 1998, 339:1044-1053.
Mata et al., “Parkin genetics: one model for Parkinson's disease,”Hum. Mol. Genet., 2004, 13:R127-R133.
Paisáan-Ruiz et al., “Cloning of the Gene Containing Mutations that CausePARK8-Linked Parkinson's Disease,”Neuron, 2004, 44:595-600.
Pals et al., “α-Synuclein Promoter Confers Susceptibility to Parkinson's Disease,”Ann. Neurol., 2004, 56:591-595.
Polymeropoulos et al., “Mutation in the α-Synuclein Gene Identified in Families with Parkinson's Disease,”Science, 1997, 276:2045-2047.
Simon et al., “‘Nature versus murture’ and incompletely penetrant mutations,”J. Neurol. Neurosurg. Psychiatry, 2002, 72:686-688.
Singleton et al., “α-Synuclein Locus Triplication Causes Parkinson's Disease,”Science, 2003, 302:841.
Slatkin and Rannala, “Estimating allele age,”Annu. Rev. Genomics Hum. Genet., 2000, 1:225-249.
Spillantini et al., “α-Synuclein in Lewy bodies,”Nature, 1997, 388:839-840.
Tanner et al., “Parkinson Disease in Twins: An Etiologic Study,”JAMA, 1999, 281(4):341-346.
Valente et al., “Hereditary Early-Onset Parkinson's Disease Caused by Mutations inPINK1, ”Science, 2004, 304:1158-1160.
Vila and Przedborski, “Genetic clues to the pathogenesis of Parkinson's disease,”Nat. Med., 2004, 10 Suppl:S58-S62.
Wirdefeldt et al. “No evidence for heritability of Parkinson disease in Swedish twins,”Neurology, 2004, 63:305-311.
Zarranz et al., “The New Mutation, E46K, of α-Synuclein Causes Parkinson and Lewy Body Dementia,”Ann. Neurol, 2004, 55:164-173.
Zimprich et al., “Mutations inLRRK2Cause Autosomal-Dominant Parkinsonism with Pleomorphic Pathology,”Neuron, 2004, 44:601-607.
Zimprich et al., “The PARK8 locus in autosomal dominant parkinsonism: confirmation of linkage and further delineation of the disease-containing interval,”Am. J. Hum. Genet., 2004, 74:11-19.
Aasly Jan O.
Farrer Matthew J.
Wszolek Zbigniew K.
Fish & Richardson P.C.
Hama Joanne
Mayo Foundation for Medical Education and Research
LandOfFree
Polynucleotide does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polynucleotide, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polynucleotide will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4134296