Polynucleotide

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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Details

C435S325000, C435S320100, C536S024100

Reexamination Certificate

active

06949361

ABSTRACT:
The present invention relates to a polynucleotide comprising a ubiquitous chromatin opening element (UCOE) that does not occur in nature. The present invention also relates to a vector comprising the polynucleotide sequence, a host cell comprising the vector and use of the polynucleotide, vector or host cell in therapy, or for in vitro protein expression applications.

REFERENCES:
Ng et al., Mol. Cell. Biol., vol. 5, 1985, pp. 2720-2732.
Verma et al., Nature, vol. 389, 1997, pp. 239-242.
Anderson, Nature, vol. 392 (suppl.), 1998, pp. 25-30.
Juengst, Brit. Med. J., vol. 326, pp. 1410-1411.
Antequera, F. & Bird, A., “Number of CpG islands and genes in human and mouse”Proc. Natl. Acad. Sci. USA, 1993, 90, 11995-11999.
Bell, A.C. & Felsenfield, G., “Stopped at the border: boundaries and insulators”Curr. Opin. Genet. Dev.,1999, 9, 191-198.
Bird et al., A fraction of the mouse genome that is derived from islands of nonmethylated, CpG-rich DNA,Cell, 1985, 40:91-99.
Dillon, N. & Grosveld, F., “Chromatin domains as potential units of eukaryotic gene function”Curr. Opin. Genet. Dev., 1994, 4, 260-264.
Hammer, et al., “Production of transgenic rabbits, sheep and pigs by microinjection”Nature, 1985, 315:680-683.
Hicks, et al., “Functional genomics in mice by tagged sequence mutagenesis”Nature Genetics, 1997, 16, 338-344.
Kioussis, D. & Festenstein, R., “Locus control regions: overcoming heterochromatin-induced gene inactivation in mammals”Curr. Opin. Genet. Dev.,1997, 7, 614-619.
Needham, et al., “Further development of the locus control region/murine erthroleukemia expression system:high level expression and characterization of recombinant human calcitonin receptor”Protein Expr. Purif., 1995, 6:124-131.
Sabbattini, P., Georgiou, A., Sinclaire, C. & Dillon, N., “Analysis of mice with single and multiple copies of transgenes reveals a novel arrangement for the λ5-V-preBI locus control region”Mol. Cell. Biol, 1999,19, 671-679.
Tazi, J. & Bird, A., “Alternative chromatin structure at CpG islands”,Cell60,1990, 909-920.

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