Polynucleoside chain having multiple ribonucleosides, the nucleo

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

514 43, 514 44, C07H 2102

Patent

active

060137851

ABSTRACT:
The invention provides a cationic polynucleoside chain having multiple nucleosides, the nucleosides being coupled together by positively charged guanidyl linkages.

REFERENCES:
patent: 4999421 (1991-03-01), Brunck et al.
patent: 5141849 (1992-08-01), Chou
patent: 5264564 (1993-11-01), Matteucci
Dempcy et al.(I), "Design and Synthesis of Deoxynucleic Guanidine: A Polycation Analogue of DNA," Proc. Nat. Acad. Sci. USA, 91, 7864-7868 (Aug. 1994).
Zon, "Oligonucleotide Analogues as Potential Chemotherapeutic Agents," Pharmaceutical Research, 5(9), 539-549 (1988).
Vanderdreissche et al.(I), "Synthesis, Enzymatic Stability and Base-Pairing Properties of Oligothymidylates Containing Thymidine Dimers with Different N-Substituted Guanidine Linkages," J. Chem. Soc., Perkin Trans I, 1993, 1567-1575.
Vanderdreissche et al.(II), "Synthesis of Novel N-Substituted Guanidine Linked Nucleoside Dimers and Their Incorporation into Oligonucleotides," Bioorg. & Medicinal Chem. Letters,, 3(2), 193-198(1993).
Dempcy et l.(II), "Synthesis of a Thymidyl Pentamer of Deoxyribonucleic Guidine and Binding Studies with DNA Homopolynucleotides," Proc. Nat. Acad. Sci. USA, 92, 6097-6101 (Jun. 1995).
Browne et al., "Binding Studies of Cationic Thymidyl Deoxyribonucleic Guanidine to RNA Homopolynucleotides," Proc. Nat. Acad. Sci. USA, 92, 7051-7055 (Jul. 1995).
Dempcy et al. (III), "Synthesis of the Polycation Thymidyl DNG, Its Fidelity in Binding Polyanionic DNA/RNA, and the Stability and Nature of the Hybrid Complex," J. Am. Chem. Soc., 117(22), 6140-6141 (1995).
Theophilus et al., "Fundamental Principles and Diagnostic Applications of Molecular Biology," Ch. 1 in Molecular and Antibody Probes in Diagnosis, Walker and Rapley eds., John Wiley & Sons, New York, NY, 1993, pp. 3-39.
Gura, "Antisense Has Growing Pains--Efforts to Develop Antisense Compounds for Cancer, AIDS, and Other Diseases Have Encountered Some Unexpected Questions About How the Drugs Really Work," Science, 270, 575-577 (Oct. 27, 1995).
Krieg et al., "CpG Motifs in Bacterial DNA Trigger Direct B-Cell Activation," Nature, 374, 546-549 (Apr. 6, 1995).
Stein, C.A., and Cheng, Y.-C. (1993) Antisense Oligonucleotides as Therapeutic Agents--Is the Bullet Really Magical?, Science 261:1004 (Exhibit 4) (Aug.).
Almarsson, Orn and Bruice Thomas C. (1993) Peptide Nucleic Acid (PNA) Conformation and Polymorphism in PNA-DNA and PNA-RNA Hybrids, Proc. Nat. Acad. Sci. USA, 90:9542-9546 (Exhibit 5) (Oct.).
Agrawal, S., et al. (1991) Pharmacokinetics, Biodistribution, and Stability of Oligodeoxynucleotide Phosphorothioates in Mice, Proc. Natl. Acad. Sci. USA 88:7595 (Exhibit 6) (Sep.).
Fanton, E.; Gelas, J., and Horton D. (1980) Novel Modes for Selective Protection of Ketose Sugars and Oligosaccharides of Biological and Industrial Importance, J. C. S., Chem. Comm., (Exhibit 7), 21-22.
Maniatis, Sambrook, Fritsch, and Maniatis, (1989) Conditions of Hybridization of Oligonucleotide Probes, Molecular Cloning: A Laboratory Manual, p. 11.45-49, Cold Spring Harbor Press (Exhibit 8).
Vorbruggen, H.; Niedballa, U.; Krolikiewicz, K.; Bennua, B.; Hofle, G. (1978) On The Mechanism of Nucleoside Synthesis, Chemistry and Biology of Nucleosides and Nucleotides, Academic Press, Inc. p. 251-265 (Exhibit 9).
Vorbruggen, H.; Hofle G. (1981) On the Mechanism of Nucleoside Synthesis. Chem. Ber. 114:256-1268 (Exhibit 10).
Saneyoshi, M.; Fujii, T.; Kawaguchi, T.; Sawai, K.; Kimura, S. (1991) 3'-Amino-2'.3'-dideoxycytidine and 3'-amino-3' deoxythymidine. Their 5'-Triphosphates: An Improved Synthesis. Convenient Reduction of Azidonucleosides and Azidonucleotides by Hydrogen Sulfide, Nucleic Acid Chemistry, Section III: Nucleosides, New York, pp. 67-72 (Exhibit 11).
Horwitz, J. P.; Tomson, A. J.; Urbanski, J. A.; Chua, J. (Sep. 1962) Nucleosides. 5'-Amino-5'-deoxyuridine and 5'-Amino-5'deoxythymidine.sup.1a,b, J. Org. Chem. 27:3045-3048 (Exhibit 12).
Brooks, B. R.; Bruccoleri,R. E.: Olafson, B. D.; States, D. J.; Swaminathan, S.; Karplus, M. (1983) CHARMM: A Program for Macromolecular Energy, Minimization, and Dynamics Calculations, J. Comput. Chem. 4:187-217 (Exhibit 13).
Camerman, N.; Fawcett, J. K.; Camerman, A. (1976) Molecular Structure of a Deoxyribose-dinucleotide, Sodium Thymidylyl-(5'j 3')-Thymidylate-(5') Hydrate (pTpT), and a Possible Structural Model for Polythymidylate, J. Mol. Biol. 107:601-621 (Exhibit 14).
Luger, P.; Paulsen H. (1976) Rontgenstrukturanalyse von Tri-O-acetyl-.beta.-D-xylopyranosylazid zur Untersuchung des Exoanomeren Effekts der Azidogruppe, Acta Cryst B32:2774-2779 (Exhibit 15).
Almarsson, O.; Bruice, T. C.; Kerr, J.; Zuckermann, R. N. (Aug. 1993) Molecular Mechanics Calculations of the Structures of Polyamide Nucleic Acid DNA Duplexes and Triple Helical Hybrids, Proc. Natl. Acad. Sci. USA, 90:7518-7522 (Exhibit 16).
Raghunathan, G.; Miles, H. T.; Sasisekharan, V. (1993) Symmetry and Molecular Structure of a DNA Triple Helix: d(T).eta..d(A).eta.ld(T).eta., Biochemistry 32:455-462 (Exhibit 17) (Issue No. 2).
Glinski,r. P.; Khan, M. S.; Kalamas, R. L. (1973) Nucleotide Synthesis, IV. Phosphorylated 3'-Amino3'-deoxythymidine and 5'-Amino-5'-deoxythymidine and Derivatives, J. Org. Chem. 38(25):4299-4305 (Exhibit 18) (Issue No. 25).
Buschauer, A. (1989) Synthesis and in Vitro Pharmacology of Arpromidine and Related Phenyl(pyridylalkyl)guanidines, a Potential New Class of Positive Inotropic Drugs, J. Med. Chem., 32:1963-1970 (Exhibit 19) (Issue No. 8).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Polynucleoside chain having multiple ribonucleosides, the nucleo does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polynucleoside chain having multiple ribonucleosides, the nucleo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polynucleoside chain having multiple ribonucleosides, the nucleo will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1463434

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.