Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1996-03-25
1998-06-09
Knode, Marian C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 235, 536 243, 536 2431, 536 2433, 536 2522, 530300, 530350, 4352523, C07H 2102, C07H 2104
Patent
active
057635919
ABSTRACT:
The present invention provides polynucleic acid sequences that are functionally associated with autoimmune diseases, such as, for example, insulin-dependent diabetes mellitus. Significantly, quantities of transcriptional and translational product encoded by the invention polynucleic acid sequences are elevated in mammals having a predisposition to autoimmune disease, as compared to their quantities in normal mammals. In accordance with the present invention, there also are provided polypeptides encoded by the invention polynucleic acid sequences, antibodies that are capable of binding to the invention polypeptides, as well as methods and kits for screening for autoimmune diseases.
REFERENCES:
patent: 4623619 (1986-11-01), Owerbach et al.
patent: 5039606 (1991-08-01), Nepon
patent: 5059519 (1991-10-01), Owerbach
patent: 5310893 (1994-05-01), Erlich et al.
D. Raum, et al., 1 (8128):1208-10 Lancet (1979).
D. Stetler, et al., 82(23):8100-4 Proc. Natl. Acad. Sci. USA (Dec. 1985).
B. Michelsen, et al., 79(4):114-52 J. Clin. Invest. (1987).
J.A. Todd, et al., 4(5):129-34 Trends Genet. (1988).
C. Julier, et al., 354:155-159 Nature (Nov. 1991).
P. Rubinstein, 30:270-7 Human Immunology (1991).
T. Hawkins, et al., 202:201-5 Proc. Soc. Exp. Biol. Med. (1993).
H.S. Fox, 175:1409-12 J.Exp. Med. (1992).
J.A. Todd, et al. 41:1029-34 Diabetes (1992).
J.A. Todd, 14(1):33-58 Springer Semin. Immunopathol. (1992).
P. Patel, et al., 36(4):264-5 Immunogenetics (1992).
S.C. Bain, et al., 2:212-15 Nat. Genet. (1992).
A.M. Lucassen, et al., 4:305-10 Nat. Genet. (1993).
D. Owerbach, et al., 42:1708-14 Diabetes (1993).
H. Ikegami, et al., 20(1):7-10 Diabetes Res. Clin. Pract. (1993).
K. Chesnut, et al., 4:549-54 Mamm. Genome (1993).
J.L. Davies, et al., 371:130-136 Nature (1994).
L. Hashimoto, et al., 371:161-64 Nature (1994).
L. Leigh Field, et al., 8:189-94 Nat. Genet. (1994).
S.T. Bennett, et al., 9:284-92 Nat. Genet. (1995).
Kennedy, et al., 9:293-98 Nat. Genet. (1995).
Ito et al Science vol. 249 (1990) pp. 790-793.
Chen et al Journal of Lipid Research vol. 35 (1994) pp. 1918-1924.
Formby Bent
Toyoda Hiroo
Amzel Viviana
Bakalyar Heather
Cedars-Sinai Medical Center
Knode Marian C.
LandOfFree
Polynucleic acid sequences that are functionally associated with does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polynucleic acid sequences that are functionally associated with, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polynucleic acid sequences that are functionally associated with will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2200671