Polynucleic acid sequences that are functionally associated with

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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536 235, 536 243, 536 2431, 536 2433, 536 2522, 530300, 530350, 4352523, C07H 2102, C07H 2104

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active

057635919

ABSTRACT:
The present invention provides polynucleic acid sequences that are functionally associated with autoimmune diseases, such as, for example, insulin-dependent diabetes mellitus. Significantly, quantities of transcriptional and translational product encoded by the invention polynucleic acid sequences are elevated in mammals having a predisposition to autoimmune disease, as compared to their quantities in normal mammals. In accordance with the present invention, there also are provided polypeptides encoded by the invention polynucleic acid sequences, antibodies that are capable of binding to the invention polypeptides, as well as methods and kits for screening for autoimmune diseases.

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