Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2003-02-21
2009-11-03
Moran, Marjorie (Department: 1631)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C435S288400, C435S288700
Reexamination Certificate
active
07612184
ABSTRACT:
The present invention is directed to a sequence dependent polynucleotide nanomechanical device based on a nucleic acid paranemic crossover (PX) molecule which is a four-stranded structure related to parallel double crossover molecules, except that every possible crossover takes place. Eliminating two crossovers leads to a topoisomer, termed JX2, in which one pair of ends are switched (rotated 180°) while the other pair of ends remain the same. The device can be cycled between the two states, PX and JX2, by replacing single strands that set the state to be PX or JX2.
REFERENCES:
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Seeman, DNA nicks and nodes and nanotechnology,Nano Letters, 1(1):22-26 (2000).
Mao et al., A nanomechanical device based on the B-Z transition of DNA,Nature, 197:144-146 (1999).
Yurke et al., a DNA-fuelled molecular machine made of DNA,Nature, 406:605-608 (2000).
Seeman, in the nick of space: Generalized nucleic acid complementarity and DNA nanotechnology,Synlett. 11:1536-1548 (2000).
Seeman Nadrian
Shen Zhiyong
Yan Hao
Zhang Xiaoping
Browdy and Neimark PLLC
Moran Marjorie
Negin Russell S
New York University
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