Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Patent
1994-05-26
1999-08-24
Teng, Sally P.
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
435 694, 4352523, 43525411, 4353201, 435325, 435440, 536 231, 536 2351, C12N 1511, C12N 1510
Patent
active
059424125
ABSTRACT:
The present invention provides novel IGF-I receptor subunits characterized by modified IGF-I receptor function, novel polynucleic acid sequences that encode these receptor subunits, and various applications for their use.
REFERENCES:
White, M.F., et al. "Mutation of the Insulin Receptor at Tyrosine 960 Inhibits Signal Transmission but Does Not Affect its Tyrosine Kinase Activity", Cell, 54:614-649, 1988.
Kapeller, R. et al., "Mutations in the Juxtamembrane Region of the Insulin Receptor Impair Activation of Phosphatidylinositol 3-Kinase by Insulin", Molec. Endocrin., 5(6):769-777 (1991).
Yamasaki, H. et al., "Pituitary Insulin-like Growth Factor I Receptor Signaling: Critical Role of Receptor Beta Subunit .sup.950 Tyrosine for Insulin-Like Growth Factor I Signal Transduction", Clinical Research, 40(1):24A, (1992).
Thies et al., J. of Biol. Chem., 265, 10132-10137, Jun. 15, 1990.
Rajagopalan et al., J. Biol. Chem., 266, 23068-23073, Dec. 5, 1991.
Ellis et al., Cell, vol. 45, pp. 721-732, 1986.
McClain et al., J. Biol. Chem., vol. 262, 14663, 1987.
Ullrich et al., Embo Journal, vol. 5, 2503, 1986.
Yamasaki, et al., "Structure-Function of the Human Insulin-Like Growth Factor-I Receptor: A Discordance of Somatotroph Internalization and Signaling." Mol. Endocrinology, vol. 7: 681-685 (1993).
Pietrzkowski, et al., "Inhibition of Cellular Proliferation by Peptide Analogues of Insulin-like Growth Factor 1.sup.1," Cancer Research, vol. 52 (Dec. 1, 1992), pp. 6447-6451.
Krane, et al., "The Insulin-like Growth Factor I Receptor Is Overexpressed in Psoriatic Epidermis, but Is Differentially Regulated from the Epidermal Growth Factor Receptor," J. Exp. Med., vol. 175 Apr. 1992, pp. 1081-1090.
Pietrzkowski, et al., "Inhibition of Growth of Prostatic Cancer Cell Lines by Peptide Analogues of Insulin-like Growth Factor 1.sup.1," Cancer Research, vol. 53, Mar. 1, 1993, pp. 1102-1106.
Kato, et al., "Role of Tyrosine Kinase Activity in Signal Transduction by the Insulin-like Growth Factor-I (IGF-I) Receptor," The Journal of Biological Chemistry, vol. 268, No. 4, Feb. 5, 1993, pp. 2655-2661.
Xiong, et al., "Growth-stimulatory monoclonal antibodies against human insulin-like growth factor I receptor," Proc. Natl. Acad. Sci. USA, vol. 89, Jun. 1992, pp. 5356-5360.
Siegfried, et al., "A mitogenic peptide amide encoded within the E peptide domain of the insulin-like growth factor IB prohormone," Proc. Natl. Acad. Sci. USA, vol. 89, Sep. 1992, pp. 8107-8111.
Herskowitz, "Functional inactivation of genes by dominant negative mutations," Nature, vol. 329, Sep. 17, 1987, pp. 219-222.
Moxham, et al., "Insulin-like Growth Factor I Receptor-Subunit Heterogeneity" The Journal of Biological Chemistry, vol. 264, No. 22, Aug. 5, 1989, pp. 13238-13244.
Yamasaki, et al., "Insulin-Like Growth Factor-I (IGF-I) Attenuation of Growth Hormone is Enhanced by Overexpression of Pituitary IGF-I Receptors," Molecular Endocrinology, vol. 5, No. 7, 1991, pp. 890-896.
Soos, et al., "Receptors for insulin and insulin-like growth factor-I can form hybrid dimers," Biochem. J., vol. 270, 1990, pp. 383-390.
Maegawa, et al., "Insulin Receptors with Defective Tyrosine Kinase Inhibit Normal Receptor Function at the Level of Substrate Phosphorylation," The Journal of Biological Chemistry, vol. 263, No. 25, Sep. 5, 1988, pp. 12629-12637.
Prager, et al., "Human Insulin-like Growth Factor I Receptor Function in Pituitary Cells Is Suppressed by a Dominant Negative Mutant," J. Clin. Invest, vol. 90, Nov. 1992, pp. 2117-2122.
Osborne, et al., "Regulation of Breast Cancer Growth By Insulin-like Growth Factors," J. Steroid Biochem. Molec. Biol., vol. 37, No. 6 1990, pp. 805-809.
Pollak, et al., Tamoxifen reduces Serum insulin-like growth factor I (IGF-I), Breast Cancer Research and Treatment, vol. 22, 1992, pp. 91-100.
Polychronakos, et al., "Mitogenic Effects of Insulin and Insulin-like Growth Factors on PA-III Rat Prostate Adenocarcinoma Cells: Characterization of the Receptors Involved," The Prostate, vol. 19, 1991, pp. 313-321.
Yamasaki, et al., "Human Insulin-like Growth Factor I Receptor.sup.950 Tyrosine Is Required for Somatotroph Growth Factor Signal Transduction," The Journal of Biological Chemistry, vol. 267, No. 29, Oct. 15, 1992, pp. 20953-20958.
Melmed Shlomo
Prager Diane
Cedars-Sinai Medical Center
Teng Sally P.
LandOfFree
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