Polymyxin synthetase and gene cluster thereof

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...

Reexamination Certificate

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C435S183000, C435S252300, C435S320100, C536S023200

Reexamination Certificate

active

07811790

ABSTRACT:
The present invention relates to a polymyxin synthetase isolated from Gram-positivePaenibacillussp. and a gene cluster encoding the same, more precisely a polymyxin synthetase isolated fromPaenibacillus polymyxaE681, a gene cluster encoding thereof and a preparation method of polymyxin or its derivatives using the gene cluster. The polymyxin synthetase of the present invention can be effectively used for the increase of productivity of polymyxin and the development of a novel antibiotic.

REFERENCES:
Beck et al. (2003) Novel pyrazine metabolites found in polymyxin biosynthesis byPaenibacillus polymyxa. FEMS Microbiology Letters, 220:67-73.
Paulus (1975) Polymyxin synthetase: L-2,4-diaminobutyrate activating enzyme. Methods Enzymol. 43:579-84.
Balakrishnan et al. (1980) Biosynthesis of polymyxin byBacillus Polymyxa. II. On the nature and interaction of the multienzyme complex with the end product polymyxin. Archives of Biochemistry and Biophysics. 200(1):45-54.
Komura et al. (1979) Partial purification and properties of L-2, 4-diaminobutyric acid activating enzyme from a polymyxin E producing organism. J. Biochem. 86:1013-1021.
Choi, et al., Identification of a Polymyxin Synthetase Gene Cluster ofPaenibacillus polymyxaand Heterologous Expression of the Gene inBacillus subtilis, Journal of Bacteriology, May 2009, pp. 3350-3358, vol. 191, No. 10, American Society for Microbiology.

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