Polymyxin B conjugates

Details Polymyxin B conjugates Polymyxin B conjugates

1990-11-01

1993-01-05

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 11, 530317, 530319, 530322, A61K 3710, A61K 3702, C07K 500, C07K 700

Patent

active

051770598

ABSTRACT:
Polymyxin B carrier conjugates, especially polymyxin B-dextran, are water soluble, have a greater half-life in the bloodstream and are significantly less toxic than native polymyxin B.

REFERENCES:
patent: 4766106 (1988-08-01), Katre et al.
Snezhko et al., 1972, Moscow Textile Institute, 1972, pp. 1-8.
Zalipsky et al, Eur. Polym J., vol. 19, No. 12, 1983, pp. 1177-1183.
LaPort et al, Biochemistry, vol. 16, No. 8, 1977, pp. 1642-1648.
Biosis Abstract 85:421296 Kitagawa et al. 1985 "Sensitive Enzyme Immunoassay of Colistin . . . " J. Assoc. Off. Anal. Chem. 68(4):661-664.

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