Polymorphs of memantine hydrochloride

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

Reexamination Certificate

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Reexamination Certificate

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07462743

ABSTRACT:
A crystalline Form II of memantine hydrochloride, pharmaceutical compositions containing crystalline Form II, and methods of preparing crystalline Forms I and II of memantine hydrochloride are provided.

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Gerzon, et al. “The Adamantyl Group in Medicinal Agents. I. Hypoglycemic N-Arylsulfonyl-N′-Adamantylureas”J. Medicinal Chemistry, vol. 6, p. 760-763 (1963).
Henkel, et al. “Structure-Anti-Parkinson Activity Relationships in the Aminoadamantanes. Influence of Bridgehead Substitution”J. Medicinal Chemistry, vol. 25, p. 51-56, (1982).

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