Polymorphs of donepezil hydrochloride and process for production

Details Polymorphs of donepezil hydrochloride and process for production Polymorphs of donepezil hydrochloride and process for production

1997-06-06

1999-11-16

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514319, 514321, 514357, 514408, 514422, 514429, 540484, 540596, 540611, 540612, 546197, 546206, 548400, 548526, 548529, A01N 4340, A01N 4346, C07D21120, C07D20700

Patent

active

059858648

ABSTRACT:
Donepezil hydrochloride, 1-benzyl-4-[(5,6-dimethoxy-1-indanon)-2-yl]methylpiperidine hydrochloride, is provided here in the form of four polymorphs which are stable against heat and humidity in the pharmaceutical use. They can be industrially produced. They are specified by peaks in X-ray powder diffraction pattern and absorption peaks in infrared absorption spectra in potassium bromide.

REFERENCES:
patent: 4895841 (1990-01-01), Sugimoto et al.
Haleblian et al, Chemical Abstract, vol. 71 No. 105142, "Pharmaceutical Application of Polymorphism" (1969).
Sabon et al, Chemical Abstract, vol. 91 No. 112384, "Polymorphism and Solubility" (1979).
Brown, Chemical Abstract, vol. 73 No. 80415, "Pharmaceutical Reviews" (1970).

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