Polymorphs of clopidogrel hydrogensulfate

Details Polymorphs of clopidogrel hydrogensulfate Polymorphs of clopidogrel hydrogensulfate

2006-07-11

2006-07-11

Tsang, Cecila J. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S120000

Reexamination Certificate

active

07074928

ABSTRACT:
Provided are new crystalline Forms III, IV, V and VI of clopidogrel hydrogensulfate and the amorphous form of clopidogrel hydrogensulfate, as well as their pharmaceutical compositions, and method of treatments with such compositions. Also provided are novel processes for preparation of clopidogrel hydrogensulfate Form I, Form II, Form III, Form IV, Form V, Form VI and amorphous form.

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Reist et al., “Very Slow Chiral Inversion of Clopidogrel in Rats: A Pharmacokinetic and Mechanistic Investigation,” Drug Metabolism and Disposition, vol. 28, No. 12, Sep. 11, 2000, pp. 1405-1410.
Harry G. Brittain (Editor) “Polymorphism in Pharmaceutical Solids” Drugs and the Pharmaceutical Sciences, vol. 95, (1999) Marcel Dekker, Inc., New York, New York.

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