Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-03-06
2007-03-06
McKane, Joseph K. (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
10489686
ABSTRACT:
The invention relates to new crystalline forms I and II of (4R-cis)-6-[2-[3-phenyl-4-(phenyl-carbamoyl)-2-(4-fluoro-phenyl)-5-(1- methyl-ethyl)-pyrrol-1-yl]-ethyl]-2,2-dimethyl-[1,3]dioxane-4-yl-acetic acid-tertiary butyl ester of the Formula (I) and a process for the preparation thereof. The new polymorphs of the present invention are useful pharmaceutical intermediates which can be used in the preparation of the hydroxymethyl-glutaryl coenzyme (HMG-COA) reducing enzyme inhibitor having the INN (International Non-proprietory Name) atorvastatin
REFERENCES:
patent: 5003080 (1991-03-01), Butler et al.
patent: 5103024 (1992-04-01), Millar et al.
patent: WO 02/059087 (2002-08-01), None
US Pharmacopia #23, National Formulary #18 (1995).
Brittain, Polymorhphism in Pharmaceutical Solids, Marcell Dekker, p. 235-236 (1995).
Barkoczy Jozsef
Bartha Ferenc
Greff Zoltan
Kirallyi Zsuzsa Szent
Kotay Nagy Peter
EGIS Gyogyszergyar Rt.
Freistein Andrew B.
McKane Joseph K.
Myers Jonathan
Wilford Andrew
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