Polymorphous forms of rifaximin, processes for their...

Details Polymorphous forms of rifaximin, processes for their... Polymorphous forms of rifaximin, processes for their...

2006-05-16

2006-05-16

Kifle, Bruck (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

active

07045620

ABSTRACT:
Crystalline polymorphous forms of the rifaximin (INN) antibiotic named rifaximin α and rifaximin β, and a poorly crystalline form named rifaximin γ have been discovered. These forms are useful in the production of medicinal preparations for oral and topical use and can be obtained by means of a crystallization process carried out by hot-dissolving the raw rifaximin in ethyl alcohol and by causing the crystallization of the product by the addition of water at a determinate temperature and for a determinate period of time. The crystallization is followed by drying carried out under controlled conditions until a specific water content is reached in the end product.

REFERENCES:
patent: 4341785 (1982-07-01), Marchi et al.
patent: 4557866 (1985-12-01), Cannata
patent: 0 161 534 (1985-11-01), None

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