Polymorphisms related to lipid metabolism: ApoB, ApoCII, ApoE, A

Details Polymorphisms related to lipid metabolism: ApoB, ApoCII, ApoE, A Polymorphisms related to lipid metabolism: ApoB, ApoCII, ApoE, A

1986-08-26

1988-09-20

Marantz, Sidney

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435810, 436 63, 436 94, 436501, 436503, 536 27, 935 11, 935 78, 935 79, C12Q 168, G01N 33566, C07H 2100

Patent

active

047725494

ABSTRACT:
Polymorphisms in genes related to lipid metabolism, specifically apolipoproteins B, CII, E, and apoAIV, have been identified. Presence or absence of these polymorphisms in particular individuals may be correlated with propensity to show symptoms of atherosclerosis. Also thus correlated are two insertion polymorphisms 5' of the insulin gene.

REFERENCES:
patent: 4623619 (1986-11-01), Owerbach et al.
Kennell, D. E., "Principles and Practices of Nucleic Acid Hybridization", Davidson & Cohn, ed., Prog. in Nucl. Acid Res. & Mol. Biol. 11, 259-301 (1971).
Wallis, S. C. et al, "The Isolation of a Genomic Clone . . . ", Human Genetics 68, 286-289 (Dec. 84).
Fojo, S. S. et al, "Analysis of the ApoCII Gene . . . ", Biochem. Biophys. Res. Comm. 124(1), 308-313 (10/15/84).
Cohen, T. et al., "DNA Polymorphic Sites in the Human . . . ", Nucleic Acid & Research RFLP Report 14(4), 1924 (2/25/86).
Priestly, L. et al, "RFLP for the Human Apolipoprotein B Gene: III; EcoRV", Nucleic Acid & Res. RFLP Report 13(18), 6791 (9/25/85).
Das, H. K. et al, "Isolation, Characterization, . . . Human Apolipoprotein E Gene", J. Biol. Chem 260(10), 6240-6247 (5/25/85).
Mandrup-Poulsen, T. et al, "DNA Sequences . . . ", The Lancet, Feb. 4, 1984, pp. 250-252.
Antonarakis et al., Proc. Natl. Acad. Sci. U.S.A., 79: 137-141 (1982).
Giannelli et al., Lancet, pp. 239-241 (2/4/84).
Grunebaun et al., J. Clin. Invest., 73: 1491-1495 (1984).
Gusella et al., Nature, 306: 234-239 (1983).
Jeffreys, Cell 8 (1979).
Kan and Dozy, Proc. Natl. Acad. Sci. U.S.A., 75 (11): 5631-5635 (1978).
Law et al., Gene, 28: 153-158 (1984).
Phillips, "The Growth Hormone (hGH) Gene and Human Disease" in Recombinant DNA: Application to Human Disease, (Eds. C. T. Gaskey and R. L. White), CSH 1983.
Rotwein et al., Science 213: 117-1120 (1981).
Taylor et al., Nature, 251: 392-393 (1984).
Woo et al., Nature, 306: 151-155 (1983).
Humphries et al., Mol. Bio. Med., 1: 463-471, (1984), "A DNA Polymorphism Adjacent to the Human Apolipoprotein CII Gene".
Priestly, L. et al, Nucleic Acids Research, 13: (18): 6789, (1985), "RLFP for the Human Apolipoprotein B Gene: I; BamHI".
Priestly, L. et al, Nucleic Acids Research, 13: (18): 6790, (1985), "RLFP for the Human Apolipoprotein B Gene: II: EcoRI".
Priestly, L. et al., Nucleic Acids Research, 13: (18): 6792, (1985), "RFLP for the Human Apolipoprotein B Gene: IV; MspI".
Priestly, L. et al, Nucleic Acids Research, 13: (18): 6793, (1985), "RFLP for the Human Apolipoprotein B Gene: V; XbaI".

Affiliated with

Also associated with

Rating

Polymorphisms related to lipid metabolism: ApoB, ApoCII, ApoE, A does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polymorphisms related to lipid metabolism: ApoB, ApoCII, ApoE, A, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polymorphisms related to lipid metabolism: ApoB, ApoCII, ApoE, A will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1748279