Polymorphisms in the urocortin 3 gene and their associations...

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Reexamination Certificate

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C435S091200, C536S023100

Reexamination Certificate

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07662567

ABSTRACT:
Aspects of the present invention also provide methods based on novel UCN3 nucleotide polymorphisms selected from the group consisting of AAFC03043460.1:g.8272-8281AATAATAAAT(SEQ ID NO: 9)>GGAGC, g.8208C>T, g.8265C>T, g.8287T>C, g.8412A>G, g.8426T>A, c.8786C>T, g.9074T>C, c.12609C>T, c.12621T>C, c.12667T>G and c.12669C>A , which may provide novel markers for marbling and/or subcutaneous fat. Additional aspects provide for novel methods which may comprise marker-assisted selection or marker-assisted management to improve marbling and/or subcutaneous fat depth in cattle.

REFERENCES:
Thisted R.A. ‘What is a P-value?’ (May 25, 1998) from www.stat.uchicago.edu/˜thisted, pp. 1-6.
Michal J.J. et al. ‘Association Of Urocortin 3 And Corticotrophin-Releasing Hormone Receptor 2 With Subcutaneous Fat Deposition And Marbling Score In Wagyu X Limousin F2 Cattle’ Abstract P526 from Plant & Animal Genomes XV Conference, Jan. 13-17, 2007, 1 printed page.
Juppner H. Bone (Aug. 1995) vol. 17 No. 2, Supplement, pp. 39S-42S.
Hacker U.T. et al. Gut (1997) vol. 40, pp. 623-627.
Jiang Z. et al. ‘Cross Species Association Examination of UCN3 and CRHR2 as Potential Pharmacological Targets for Antiobesity Drugs’ PLoS One (Dec. 2006; issue 1) 1(1): e80, 8 printed pages.
Tsuji et al. An association study using AFLP markers and application to a beef cattle breeding population. Animal Genetics. Feb. 2004, vol. 35, No. I, pp. 40-43.
Database DWPI on West, Derwent Acc. No. 2002-737829, Abstract of KR 415080 B (Yeo, J.S.) Jan. 13, 2004.

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