Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-10-17
2006-10-17
O'Hara, Eileen B. (Department: 1646)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S022100, C435S320100, C435S069100, C435S006120, C435S325000
Reexamination Certificate
active
07122652
ABSTRACT:
Described are general means and methods of diagnosing and treating the phenotypic spectrum as well as the overlapping clinical characteristics with several forms of inherited abnormal expression and/or function of the hPXR gene. In particular, polynucleotides of molecular variant hPXR gene which, for example, are associated with insufficient metabolization and/or sensitivity of drugs, and vectors comprising such polynucleotides are provided. Furthermore, host cells comprising such polynucleotides or vectors and their use for the production of variant hPXR proteins are described. In addition, variant hPXR proteins and antibodies specifically recognizing such proteins as well as transgenic non-human animals comprising the above-described polynucleotide or vectors are provided. Described are also methods for identifying and obtaining inhibitors for therapy of disorders related to the malfunction of the hPXR gene as well as methods of diagnosing the status of such disorders. Pharmaceutical and diagnostic compositions comprising the above-described polynucleotides, vectors, proteins, antibodies and inhibitors by the above-described method are provided. Said compositions are particularly useful for diagnosing and treating various diseases with drugs that are substrates, inhibitors or modulators of the hPXR gene product.
REFERENCES:
patent: 6821724 (2004-11-01), Mittman et al.
patent: 1 024 193 (2000-08-01), None
patent: WO 99/48915 (1999-09-01), None
Whang et al., Genomics 30: 293298, 1995.
Bertilsson, G. et al., “Identification Of A Human Nuclear Receptor Defines A New Signaling Pathway For CYP3A Induction,”Proc. Natl. Acad. Sci. USA,95:12208-12213 (1998).
Dotzlaw, H. et al., “The Human Organ Receptor PXR Messenger RNA is Expressed In Both Normal And Neoplastic Breast Tissue,”Clinical Cancer Research5:2103-2107 (1999).
Jones, S. et al., “The Pregnane X Receptor: A Promiscuous Xenobiotic Receptor That Has Diverged During Evolution,”Molecular Endocrinology,14:27-39 (2000).
Kliewer, S. et al., “An Orphan Nuclear Receptor Activated By Pregnanes Defines A Novel Steroid Signaling Pathway,”Cell92:73-82 (1998).
Lehmann, J. et al., “The Human Orphan Receptor PXR Is Activated By Compounds That Regulate CYP3A4 Gene Expression And Cause Drug Interactions,”Journal of Clinical Investigation102:1016-1023 (1998).
Pascussi, J.-M. et al., “Evidence for the Presence of a Functional Pregnane X Receptor Response Element in the CYP3A7 Promoter Gene,”Biochemical and Biophysical Research Communications,260:377-381 (1999).
Zhang, H. et al., “Rat Pregnane X Receptor: Molecular Cloning, Tissue Distribution, And Xenobiotic Regulation,”Archives of Biochemistry and Biophysics368:14-22 (1999).
Hustert Elisabeth
Wojnowski Leszek
Chandra Gyan
Gunnison Jane T.
Helm Katherine A.
O'Hara Eileen B.
Ropes & Gray
LandOfFree
Polymorphisms in the human hPXR gene and their use... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Polymorphisms in the human hPXR gene and their use..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polymorphisms in the human hPXR gene and their use... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3627785