Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2011-01-18
2011-01-18
Johannsen, Diana B (Department: 1634)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S007100, C435S019000, C435S091200, C435S091500, C435S091520, C435S183000, C536S023200, C536S023500, C536S025320
Reexamination Certificate
active
07871767
ABSTRACT:
The present invention relates to a polymorphic CYP2C8-polynucleotide. Moreover, the invention relates to genes or vectors comprising the polynucleotides of the invention and to a host cell genetically engineered with the polynucleotide or gene of the invention. Further, the invention relates to methods for producing molecular variant polypeptides or fragments thereof, methods for producing cells capable of expressing a molecular variant polypeptide and to a polypeptide or fragment thereof encoded by the polynucleotide or the gene of the invention or which is obtainable by the method or from the cells produced by the method of the invention. Furthermore, the invention relates to an antibody which binds specifically the polypeptide of the invention. Moreover, the invention relates to a transgenic non-human animal. The invention also relates to a solid support comprising one or a plurality of the above mentioned polynucleotides, genes, vectors, polypeptides, antibodies or host cells. Furthermore, methods of identifying a polymorphism, identifying and obtaining a prodrug or drug or an inhibitor are also encompassed by the present invention. In addition, the invention relates to methods for producing of a pharmaceutical composition and to methods of diagnosing a disease. Further, the invention relates to a method of detection of the polynucleotide of the invention. Furthermore, comprised by the present invention are a diagnostic and a pharmaceutical composition. Even more, the invention relates to uses of the polynucleotides, genes, vectors, polypeptides or antibodies of the invention. Finally, the invention relates to a diagnostic kit.
REFERENCES:
patent: 5403708 (1995-04-01), Brennan et al.
patent: WO 00/58508 (2000-10-01), None
patent: WO 02/08412 (2002-01-01), None
Bahudar, N. et al. CYP2C8 polymorphisms in Caucasians and their relationship with paclitaxel 6alpha-hydroxylase activity in human liver microsomes. Biochemical Pharmacology 64:1579-1589 (Dec. 2002).
Klose, T.S., Blaisdell, J.A. & Goldstein, J.A. Gene structure of CYP2C8 and extrahepatic distribution of the human CYP2Cs. J. Biochem Mol Toxicol 13, 289-95 (1999).
Gray, IC., Nobile, C., Muresu, R., Ford, S. & Spurr, N.K. A 2.4-megabase physical map spanning the CYP2C gene cluster on chromosome 10q24. Genomics 28, 328-32 (1995).
Goldstein, J.A. & de Morais, S.M. Biochemistry and molecular biology of the human CYP2C subfamily. Pharmacogenetics 4, 285-99 (1994).
Finta, C. & Zaphiropoulos, P.G. The human CYP2C locus: A prototype for intergenic and exon repetition splicing events [In Process Citation]. Genomics 63, 433-8 (2000).
Mechetner, E. et al. Levels of multidrug resistance (MDR1) P-glycoprotein expression by human breast correlate with in vitro resistance to taxol and doxorubicin. Clin Cancer Res 4, 389-98. (1998).
Tracy, T.S., Korzekwa, K.R., Gonzalez, F.J. & Wainer, I.W. Cytochrome P450 isoforms involved in metabolism of the enantiomers of verapamil and norverapamil. Br J Clin Pharmacol 47, 545-52. (1999).
Malinowski, J.M. & Bolesta, S. Rosiglitazone in the treatment of type 2 diabetes mellitus: a critical review. Clin Ther 22, 1151-68; discussion 1149-50. (2000).
Wrighton, S.A. et al. Purification of a human liver cytochrome P-450 immunochemically related to several cytochromes P-450 purified from untreated rats. J Clin Invest 80, 1017-22. (1987).
Relling, M.V., Aoyama, T., Gonzalez, F.J. & Meyer, U.A. Tolbutamide and mephenytoin hydroxylation by human cytochrome P450s in the CYP2C subfamily. J Pharmacol Exp Ther 252, 442-7. (1990).
Kerr, B.M. et al. Human liver carbamazepine metabolism. Role of CYP3A4 and CYP2C8 in 10,11-epoxide formation. Biochem Pharmacol 47, 1969-79 (1994).
Yun, C.H., Shimada, T. & Guengerich, F.P. Roles of human liver cytochrome P4502C and 3A enzymes in the 3-hydroxylation of benzo(a)pyrene. Cancer Res 52, 1868-74 (1992).
Leo, M.A., Kim, C.I. & Lieber, CS. NAD+-dependent retinol dehydrogenase in liver microsomes. Arch Biochem Biophys 259, 241-9. (1987).
Morel, F. et al. Expression of cytochrome P-450 enzymes in cultured human hepatocytes. Eur J Biochem 191, 437-44 (1990).
Thum, T. & Borlak, J. Cytochrome P450 mono-oxygenase gene expression and protein activity in cultures of adult cardiomyocytes of the rat. Br J Pharmacol 130, 1745-52. (2000).
Fisslthaler, B. et al. Cytochrome P450 2C is an EDHF synthase in coronary arteries. Nature 401, 493-7 (1999).
Fleming, I. et al. Endothelium-derived hyperpolarizing factor synthase (Cytochrome P450 2C9) is a functionally significant source of reactive oxygen species in coronary arteries. Circ Res 88, 44-51. (2001).
Meyer, U.A. & Zanger, U.M. Molecular mechanisms of genetic polymorphisms of drug metabolism, Annu Rev Pharmacol Toxicol 37, 270-96. (1997).
West, W.L., Knight, E.M., Pradhan, S. & Hinds, T.S. Interpatient variability: genetic predisposition and other genetic factors. J Clin Pharmocol 37, 635-48. (1997).
Marshall, A. Laying the foundations for personalized medicines. Nat Biotechnol 15, 954-7. (1997).
Marshall, A. Getting the right drug into the right patient. Nat Biotechnol 15, 1249-52 (1997).
Bertz, R.J. & Granneman, G.R. Use of in vitro and in vivo data to estimate the likelihood of metabolic pharmacokinetic interactions. Clin Phamacokinet 32, 210-58. (1997).
Engel, G., Hofmann, U. & Kroemer, H.K. Prediction of CYP2D6-mediated polymorphic drug metabolism (sparteine type) based on in vitro investigations. J Chromatogr B Biomed Appl 678, 93-103. (1996).
Olszewski, K.A., Kolinski, A. & Skolnick, J. Folding simulations and computer redesign of protein A three-helix bundle motifs. Proteins 25, 286-99. (1996).
Hoffman, D.L., Laiter, S., Singh, R.K., Vaisman, II & Tropsha, A. Rapid protein structure classification using one-dimensional structure profiles on the bioSCAN parallel computer. Comput Appl Biosci 11, 675-9. (1995).
Monge, A., Lathrop, E.J., Gunn, J.R., Shenkin, P.S. & Friesner, R.A. Computer modeling of protein folding: conformational and energetic analysis of reduced and detailed protein models. J Mol Biol 247, 995-1012. (1995).
Renouf, D.V. & Hounsell, E.F. Molecular modelling of glycoproteins by homology with non-glycosylated protein domains, computer simulated glycosylation and molecular dynamics. Adv Exp Med Biol 376, 37-45. (1995).
Fassina, G. & Melli, M. Identification of interactive sites of proteins and protein receptors by computer-assisted searches for complementary peptide sequences. Immunomethods 5, 114-20. (1994).
Berry, A, & Brenner, S.E. A prototype computer system for de novo protein design. Biochem Soc Trans 22, 1033-6. (1994).
Wodak, S.J. Computer-aided design in protein engineering. Ann N Y Acad Sci 501, 1-13. (1987).
Pabo, C.O. & Suchanek, E.G. Computer-aided model-building strategies for protein design. Biochemistry 25, 5987-91. (1986).
Ostresh, J.M., Blondelle, S.E., Dorner, B. & Houghten, R.A. Generation and use of nonsupport-bound peptide and peptidomimetic combinatorial libraries. Methods Enzymol 267, 220-34. (1996).
Dorner, B., Husar, G.M., Ostresh, J.M. & Houghten, R.A. The synthesis of peptidomimetic combinatorial libraries through successive amide alkylations. Bioorg Med Chem 4, 709-15. (1996).
Rose, R.B., Craik, C.S., Douglas, N.L. & Stroud, R.M. Three-dimensional structures of HIV-1 and SIV protease product complexes. Biochemistry 35, 12933-44. (1996).
Rutenber, E.E. et al. A new class of HIV-1 protease inhibitor: the crystallographic structure, inhibition and chemical synthesis of an aminimide peptide isostere. Bioorg Med Chem 4, 1545-58. (1996).
Meyer, U.A. Overview of enzymes of drug metabolism. J Pharmacokinet Biopharm 24, 449-59. (1996).
Vallett, S.M., Sanchez, H.B., Rosenfeld, J.M. & Osborne, T.F. A direct role for sterol regulatory element binding protein in activation of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene. J Biol Chem 271, 12247-53. (1996).
Dai et al., “Genetic polymorphisms of human CYP2C8 and their effects on metabolism of anticancer drug: Paclitaxel
Brinkmann Ulrich
Penger Anja
Sprenger Reimund
Johannsen Diana B
McCarter & English LLP
PGxHealth LLC
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