Polymorphism in bovine prion protein gene sequence

Details Polymorphism in bovine prion protein gene sequence Polymorphism in bovine prion protein gene sequence

2011-01-11

2011-01-11

Kapushoc, Stephen (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091200, C536S023100, C536S024300

Reexamination Certificate

active

07867710

ABSTRACT:
A specific, non-synonymous SNP in the Prnp gene encoding the bovine prion protein affects the susceptibility of bovine animals to bovine spongiform encephalopathy (BSE). Depending on the number of octapeptide repeat units present in the Prnp gene, the position of the SNP is either nucleotide 631 of exon 3 (codon 211) when the Prnp gene comprises six octapeptide repeat region sequences, nucleotide 607 of exon 3 (codon 203) when the Prnp gene comprises five octapeptide repeat region sequences, or nucleotide 655 of exon 3 (codon 219) when the Prnp gene comprises seven octapeptide repeat region sequences. Alleles of the bovine Prnp wherein the SNP at these positions is lysine (K) at the corresponding amino acids (i.e., 211, 203 or 219) in the bovine prion protein are all indicative of increased susceptibility to BSE in comparison to alleles which encode glutamic acid (E) at the same position. This SNP may be used as a marker for selecting bovines susceptible to BSE for disposal and/or removal from breeding, the human food and animal feed supplies.

REFERENCES:
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Coulthart, Michael B., et al., “Prion protein gene sequence of Canada's first non-imported case of bovine spongiform encephaloopathy (BSE)”, Genome, 46, 2003, pp. 1005-1009.
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Sander, Petra, et al., “Bovine Prion Protein Gene (PRNP) Promoter Polymorphisms Modulate PRNP Expression and May Be Responsible for Differences in Bovine Spongiform Encephalopathy Susceptibility”, The Journal of Biological Chemistry, vol. 280, No. 45, Nov. 11, 2005, pp. 37408-37414.
Heaton, Michael P., et al., “Prion gene sequence variation within diverse groups of U.S. sheep, beef cattle, and deer”, PRNP Nucleotide Diversity in US Sheep, Cattle and Deer, vol. 14, 2003, pp. 765-777.
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