Polymorphism detection and separation

Details Polymorphism detection and separation Polymorphism detection and separation

2002-09-27

2008-12-23

Bausch, Sarae (Department: 1634)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

C435S091100, C536S023100, C536S024300

Reexamination Certificate

active

07468244

ABSTRACT:
Methods and compositions for polymorphism detection and separation. The methods are readily multiplexed, can be adapted to a variety of existing detection systems, and permit target amplification without PCR. The methods permit allelic variants selectively to be isolated, with or without contemporaneous detection, and finds particular utility in facilitating the construction of coisogenic cell collections in which the cells differ genotypically by single nucleotide changes targeted to defined loci.

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