Polymorphic forms of ziprasidone and its hydrochloride salt...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C544S279000, C544S368000

Reexamination Certificate

active

07488729

ABSTRACT:
The present invention is related to crystalline forms of ziprasidone and its hydrochloride salt and an amorphous form of ziprasidone hydrochloride and the process for the preparation thereof. The crystalline forms and amorphous form of the invention are suitable for pharmaceutical purposes in the treatment of psychosis. The processes of the invention are simple, non-hazardous and commercially suitable.

REFERENCES:
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patent: 6150366 (2000-11-01), Arenson et al.
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patent: 00/59489 (2000-10-01), None
patent: 03/063833 (2003-08-01), None
patent: 03/070246 (2003-08-01), None
Lieberman, Herbert A., ed. “Pharmaceutical Dosage Forms: Tablets,” vol. 2 (1989), pp. 462-465.
Howard H.R. et al. “3-Benzisothiazolylpiperazine Derivatives as Potential Atypical Antipsychotic Agents” Journal of Medicinal Chemistry, vol. 39, No. 1—Jan. 5, 1996—pp. 143-148 (XP000652318).

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