Polymorphic forms of sertraline hydrochloride

Details Polymorphic forms of sertraline hydrochloride Polymorphic forms of sertraline hydrochloride

2005-09-06

2005-09-06

Barts, Samuel (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

C564S428000

Reexamination Certificate

active

06939992

ABSTRACT:
A crystalline form of sertraline hydrochloride was found, referred to hereinafter as polymorphic form CSC2 having a dissolution rate which surprisingly will increase rate of absorption of a drug.Furthermore, different crystalline forms of sertraline hydrochloride alcohol solvates, crystalline forms of sertraline hydrochloride hydrates, referred to hereinafter as polymorphic form CSC1, a process for the preparation of the amorphous form of sertraline hydrochloride, and different processes for the preparation of polymorphic forms I, II, V, and T1 are disclosed.

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J. B. Conant et al., Organic Syntheses, CV 1, 345.
L. G. Wade, Organic Chemistry, 2ndEd., pp. 998-1001, (1991).

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