Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-05-08
2009-10-20
Anderson, Rebecca L (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
active
07605270
ABSTRACT:
The present invention relates to polymorphic forms of (S)-tetrahydrofuran-3-yl 3-(3-(3-methoxy-4-(oxazol-5-yl)phenyl)ureido)benzylcarbamate (Compound 1):and pharmaceutical compositions thereof. The present invention also relates to processes to prepare compound 1 and pharmaceutical compositions thereof. Compound 1 is an IMPDH inhibitor useful in treating IMPDH-mediated diseases such as immune system related diseases, viral diseases, and cancers.
REFERENCES:
patent: 6541496 (2003-04-01), Armistead et al.
Byrn, et al. ed. “Comparing X-ray Powder Data”. Solid State Chemistry of Drugs, 2nd edition, p. 63.
A. Maureen Rouhi, Chemical & Engineering News, Feb. 24, 2003, pp. 32-35.
Haleblian et al. Journal of Pharmaceutical Sciences, Aug. 1969, vol. 58, No. 8, pp. 911-929.
Blythe Todd
Eberlin Alex
Hurrey Michael
Jonaitis David
Nyce Philip
Anderson Rebecca L
Badia Michael C.
Vertex Pharmaceuticals Incorporated
Young Shawquia
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