Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – N-c doai
Reexamination Certificate
2005-03-22
2010-02-09
Wilson, James O (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
N-c doai
C514S552000, C558S410000, C558S417000
Reexamination Certificate
active
07659309
ABSTRACT:
The present invention relates to polymorphic forms of (1-{3-[3-(4-cyano-3-methoxy-phenyl)ureido]-phenyl}-ethyl)-carbamic acid-2-cyano-1-ethyl-ethyl ester, processes therein, pharmaceutical compositions thereof, and uses therewith.
REFERENCES:
patent: 6498178 (2002-12-01), Stamos et al.
patent: 2002/0111378 (2002-08-01), Stamos et al.
Jain J. et al., “Characterization of Pharmacological Efficacy of VX-148, A New, Potent Immunosuppressive Inosine 5′—Monophosphate Dehydrogenase Inhibitor”, Journal of Pharmacology and Experimental Therapeutics, American Society for Pharmacology and, US, 302(3): 1272-1277 (2002).
Mino R. Caira, “Crystalline Polymorphism of Organic Compounds”, Topics in Current Chemistry, 198: 163-208 (1998).
Blythe Todd
Cui Yong
Nyce Philip
Badia Michael C.
Sackey Ebenezer
Vertex Pharmaceuticals Incorporated
Wilson James O
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