Polymorphic form of doxazosin mesylate (form III)

Details Polymorphic form of doxazosin mesylate (form III) Polymorphic form of doxazosin mesylate (form III)

1997-12-17

2000-10-31

Ford, John M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

544291, C07D40314, A61K 31517

Patent

active

061403342

ABSTRACT:
A new crystalline and anhydrous form of doxazosin mesylate is described. The new form is crystalline and anhydrous and is characterized in its X-ray spectrum by the following reflex positions of high and medium intensity: 8.49.degree., 11.72.degree., 16.03.degree., 18.29.degree., 21.03.degree., 22.87.degree. and 25.02.degree.. Owing to its crystalline properties, the new form of doxazosin mesylate according to the invention has surprising advantages both with regard to its synthesis and for pharmaceutical processing into solid dosage forms. A process for preparing the new form of doxazosin mesylate and pharmaceutical compositions comprising the new form of doxazosin mesylate are also described.

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Xu Liying et al, Chinese Journal of Medicinal Chemistry, vol. 5, No. 4, p. 266 (1995).
The Merck Index, 1996, Merck & Co., Inc., Whitehouse Station, N.J., XP002030968, #3489: Doxazosin.

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