Polymorphic crystalline forms of tiacumicin B

Details Polymorphic crystalline forms of tiacumicin B Polymorphic crystalline forms of tiacumicin B

2007-07-31

2008-05-27

Jiang, Shaojia Anna (Department: 1623)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

C549S271000

Reexamination Certificate

active

07378508

ABSTRACT:
The invention relates to novel forms of compounds displaying broad spectrum antibiotic activity, especially crystalline polymorphic forms and amorphous forms of such compounds, compositions comprising such crystalline polymorphic forms and amorphous forms of such compounds, processes for manufacture and use thereof. The compounds and compositions of the invention are useful in the pharmaceutical industry, for example, in the treatment or prevention of diseases or disorders associated with the use of antibiotics, chemotherapies, or antiviral therapies, including, but not limited to, colitis, for example, pseudo-membranous colitis; antibiotic associated diarrhea; and infections due toClostridium difficile(“C. difficile”),Clostridium perfringens(“C. perfringens”),Staphylococcusspecies, for example, methicillin-resistantStaphylococcus, orEnterococcusincluding Vancomycin-resistantenterococci.

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