Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Liposomes
Reexamination Certificate
2007-05-15
2007-05-15
Kishore, Gollamudi S. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Liposomes
C424S001210, C424S009321, C424S009510, C424S417000, C424S489000, C424S502000, C428S402200, C264S004100, C264S004300
Reexamination Certificate
active
10882816
ABSTRACT:
The present invention provides biocompatible vesicles comprising semi-permeable, thin-walled encapsulating membranes which are formed in an aqueous solution, and which comprise one or more synthetic super-amphiphilic molecules. When at least one super-amphiphile molecule is a block copolymer, the resulting synthetic vesicle is termed a “polymersome.” The synthetic, reactive nature of the amphiphilic composition enables extensive, covalent cross-linking of the membrane, while maintaining semi-permeability. Cross-linking of the polymer building-block components provides mechanical control and long-term stability to the vesicle, thereby also providing a means of controlling the encapsulation or release of materials from the vesicle by modifying the composition of the membrane. Thus, the encapsulating membranes of the present invention are particularly suited for the reliable, durable and controlled transport, delivery and storage of materials.
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Bates Frank
Discher Bohdana M.
Discher Dennis E.
Hammer Daniel A.
Lee James C-M
Kishore Gollamudi S.
McConathy, Esq. Evelyn H.
Montgomery, McCracken, Walker & Rhoads LLP
Regents of the University of Minnesota
The Trustees of the University of Pennsylvania
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