Polymers with controlled physical state and bioerodibility

Details Polymers with controlled physical state and bioerodibility Polymers with controlled physical state and bioerodibility

1997-12-05

1999-10-19

Acquah, Samuel A.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

528220, 528271, 528354, 528392, 528403, 528406, 528425, 424422, 424426, 424486, A61F 200, C08G 200

Patent

active

059685433

ABSTRACT:
Polymers useful as orthopedic implants or vehicles for the sustained delivery of pharmaceutical, cosmetic and agricultural agents are prepared in such a manner that the rate and degree to which they are hydrolyzed can be controlled without addition of exogenous acid. This control results from the incorporation of esters of short-chain .alpha.-hydroxy acids such as esters of glycolic acid, lactic acid or glycolic-co-lactic acid copolymer into the polymer chain and variation of the amount of these esters relative to the polymer as a whole.

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