Polymers for delivering nitric oxide in vivo

Details Polymers for delivering nitric oxide in vivo Polymers for delivering nitric oxide in vivo

2006-08-07

2008-08-26

Truong, Duc (Department: 1796)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

From sulfur-containing reactant

C528S422000, C528S425000, C536S016000, C536S103000, C536S122000, C536S123100, C536S126000, C424S408000, C424S422000, C601S001000

Reexamination Certificate

active

07417109

ABSTRACT:
Disclosed are novel polymers derivatized with at least one —NOxgroup per 1200 atomic mass unit of the polymer. X is one or two. In one embodiment, the polymer is an S-nitrosylated polymer and is prepared by reacting a polythiolated polymer with a nitrosylating agent under conditions suitable for nitrosylating free thiol groups. The polymers of the present invention can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites.

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