Polymers for delivering nitric oxide in vivo

Details Polymers for delivering nitric oxide in vivo Polymers for delivering nitric oxide in vivo

2005-04-05

2005-04-05

Truong, Duc (Department: 1711)

Synthetic resins or natural rubbers -- part of the class 520 ser

Synthetic resins

From sulfur-containing reactant

C528S425000, C528S422000, C536S046000, C536S103000, C536S122000, C536S123100, C536S126000, C424S408000, C424S422000, C604S001000

Reexamination Certificate

active

06875840

ABSTRACT:
Disclosed are novel polymers derivatized with at least one —NOxgroup per 1200 atomic mass unit of the polymer. X is one or two. In one embodiment, the polymer is an S-nitrosylated polymer and is prepared by reacting a polythiolated polymer with a nitrosylating agent under conditions suitable for nitrosylating free thiol groups. The polymers of the present invention can be used to coat medical devices to deliver nitric oxide in vivo to treatment sites.

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