Polymers containing cross-linked azo bonds, which polymers are u

Details Polymers containing cross-linked azo bonds, which polymers are u Polymers containing cross-linked azo bonds, which polymers are u

1988-08-12

1991-07-16

Higel, Floyd D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514150, 514 2, 514 54, 514 56, 514151, 514568, 514772, 514778, 514960, 514961, 514962, 514963, 514964, 534573, 534843, A61K 4700, C07C10700

Patent

active

050325728

ABSTRACT:
Polymers from ethylenically unsaturated monomers, cross-linked by a substituted divinylazobenzene are useful as pharmaceutical compositions for the delivery of medicaments. The polymers are degraded by the enzymes of the upper gastrointestinal tract or are transferred intact past the upper gastrointestinal tract, to deliver the medicament to the large intestine. In particular, the polymers contain divinylazobenzene compounds of the formulae ##STR1## wherein R.sub.1 and R.sub.2 are independently selected from the group consisting of H, (except that R.sub.1 and R.sub.2 are not both H), Cl, Br, I, NO.sub.2, NH.sub.2, RO, ArO, COOH or salts thereof, COOR, COOAr, CHO, COR, SO.sub.3 H or salts thereof, R or Ar and wherein R is alkyl of up to 18 carbon atoms and Ar is mono- or bicyclic aryl of up to 15 carbon atoms.

REFERENCES:
patent: 2784204 (1957-03-01), Heyna et al.
patent: 3484390 (1969-12-01), Bauman et al.
patent: 3780171 (1973-12-01), Irmscher et al.
patent: 3862107 (1975-01-01), MacLeay
patent: 3862312 (1975-01-01), Rimington et al.
patent: 3868359 (1975-02-01), Sheppard et al.
patent: 3976797 (1976-08-01), Furia
patent: 4008208 (1977-02-01), Lednicer et al.
patent: 4101269 (1978-07-01), Champenois
patent: 4129531 (1978-12-01), Rauer et al.
patent: 4140659 (1979-02-01), Clemens et al.
patent: 4190716 (1980-02-01), Parkinson et al.
patent: 4298595 (1981-11-01), Parkinson et al.
patent: 4663308 (1987-05-01), Saffran et al.
Peppercorn, Mark A. and Peter Goldman: The Role of Intestinal Bacteria in the Metabolism of Salicylazosulfapyridine, J. Pharmacol. Exp. Ther., 181:555-562, 1972.
Saffran, M.: Oral Administration of Peptides.
Endocrinologia Experimentalis, 16, 327-333, 1982.
Saffran, M., Franco-Saenz, R., Kong, A., Paphadjopoulous, D. & Szoka, F.: A Model for the Study of the Oral Administration of Peptide Hormones, Can. J. Bio. Chem., 57, 548-553, 1979.
Arcus et al., Index Chemicus, vol. 16, #49093 (1965).
Davies et al., J. Appl. Chem., vol. 9, pp. 368-371 (1959).
Ida et al., J. Pharm. Soc. Japan, vol. 89, pp. 524-530 (1969).
Kamagawa et al., Index Chemicus, vol. 32, #108283 (1969).
Martynoff, I, Chemical Abstracts, vol. 49, #8876 d,e (1955).
Martynoff, II, Chemical Abstracts, vol. 50, #914 d,e (1956).
Savvin et al., Chemical Abstracts, vol. 68, #69638K (1968).
Ueno, J. Amer. Chem. Soc., vol. 79, pp. 3205-3208 (1957).
Breitenbach, Chemical Abstracts, vol. 42, #8521 e,f (1948).
Kurilenko et al., Chemical Abstracts, vol. 79, #105711 s (1973).
Shine et al., J. Org. Chem., vol. 28, pp. 1232-1236 (1963).
Wiley et al., J. Amer. Chem. Soc., vol. 70, pp. 2295-2296 (1948).

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