Polymers containing antifibrotic agents, compositions containing

Details Polymers containing antifibrotic agents, compositions containing Polymers containing antifibrotic agents, compositions containing

1992-08-24

1994-12-13

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Nitrogen heterocycle

424 7837, A61K 3174, C07D20700

Patent

active

053728076

ABSTRACT:
The present invention concerns a method for treating fibrotic conditions by administration of an effective amount of an antifibrotic agent. The antifibrotic agent is preferably a proline analog, such as cis-4-hydroxy-L-proline (cHyp). The antifibrotic agent is operatively linked to a monomer or a polymer, with or without a linking compound, e.g., lysine. Intravenous administration is preferred. The present method facilitates the delivery and release of the antifibrotic agent to inhibit collagen accumulation and thereby to treat fibrosis where collegen metabolism is implicated. A reduced quantity of the antifibrotic agent and a corresponding reduction in the potential for toxicity resulting from prolonged administration thereof may be realized.

REFERENCES:
Am. Rev. Resp. Dis 139:A172 (Abstract) 1989.
Am. Rev. Resp. Dis. 141:A186 (Abstract) 1990.
Lubec G. et al. Amino Acids:Chemistry, Biology and Medicine pp. 634-642 (1990).

Affiliated with

Also associated with

Rating

Polymers containing antifibrotic agents, compositions containing does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polymers containing antifibrotic agents, compositions containing, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polymers containing antifibrotic agents, compositions containing will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1191772