Polymerized liposomes targeted to M cells and useful for oral or

Details Polymerized liposomes targeted to M cells and useful for oral or Polymerized liposomes targeted to M cells and useful for oral or

1997-04-18

2000-05-09

Kishore, Gollamudi S.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

436829, A61K 9127

Patent

active

060600829

ABSTRACT:
The present invention relates to targeted polymerized liposomes for oral and/or mucosal delivery of vaccines, allergens and therapeutics. In particular, the present invention relates to polymerized liposomes which have been modified on their surface to contain a molecule or ligand which targets the polymerized liposome to a specific site or cell type. More particularly, the invention relates to the use of polymerized liposomes modified to contain a carbohydrate or lectin on their surface.

REFERENCES:
patent: 4201767 (1980-05-01), Fullerton et al.
patent: 4229360 (1980-10-01), Schneider et al.
patent: 4348329 (1982-09-01), Chapman
patent: 4429008 (1984-01-01), Martin et al.
patent: 4485045 (1984-11-01), Regen
patent: 4522811 (1985-06-01), Eppstein et al.
patent: 4560599 (1985-12-01), Regen
patent: 4564475 (1986-01-01), Masaichiro
patent: 4587055 (1986-05-01), Regen
patent: 4594193 (1986-06-01), Regen
patent: 4652257 (1987-03-01), Chang
patent: 4728575 (1988-03-01), Gamble et al.
patent: 4753788 (1988-06-01), Gamble
patent: 4808480 (1989-02-01), Regen
patent: 4847080 (1989-07-01), Neurath et al.
patent: 4861621 (1989-08-01), Suzuki et al.
patent: 4867976 (1989-09-01), Ueda
patent: 4877501 (1989-10-01), Schnur et al.
patent: 4877619 (1989-10-01), Richer
patent: 4880635 (1989-11-01), Janoff et al.
patent: 4900556 (1990-02-01), Wheatley et al.
patent: 4925661 (1990-05-01), Huang
patent: 4933114 (1990-06-01), O'Brien et al.
patent: 4935171 (1990-06-01), Bracken
patent: 4975282 (1990-12-01), Cullis et al.
patent: 4976968 (1990-12-01), Steiner et al.
patent: 4990291 (1991-02-01), Schoen et al.
patent: 5000960 (1991-03-01), Wallach
patent: 5004566 (1991-04-01), Schnur et al.
patent: 5061484 (1991-10-01), Heldebrant
patent: 5104736 (1992-04-01), Wallach
patent: 5106740 (1992-04-01), Hasegawa et al.
patent: 5158769 (1992-10-01), Neurath et al.
patent: 5160740 (1992-11-01), Hasegawa et al.
patent: 5178859 (1993-01-01), Simon
patent: 5198224 (1993-03-01), Ono et al.
patent: 5204096 (1993-04-01), Neurath et al.
patent: 5230899 (1993-07-01), Park et al.
patent: 5258499 (1993-11-01), Konigsberg et al.
patent: 5366881 (1994-11-01), Singh et al.
patent: 5382435 (1995-01-01), Geary et al.
patent: 5425993 (1995-06-01), Morancais et al.
patent: 5464630 (1995-11-01), Six et al.
patent: 5505967 (1996-04-01), Geary et al.
patent: 5571718 (1996-11-01), Dunn et al.
Chol and Hahn, 1992, "Polymer-Coated Liposomes for Oral Drug Delivery", Yakchc Hakhoechi 22;211-217 (Chem. Abstr. 118:407, Abstr. No. 19/902e, 1993).
Okada et al., 1993, "Polymerized Liposomes for Oral Drug Delivery", Proc. Int. Symp. Controlled Release Bioact. Mater. pp. 302-303.
Patel et al., 1976, "Oral Administration of Insulin by Encapsulation within Liposomes", FEBS Lett. 62:60-63.
Regen, 1984, "Polymerized Vesicles", Polymer News 10:68-73.
Regen, 1987, "Polymerized Liposomes" Liposomes: From Biophysics to Therapeutics (Marcel Dekker, Inc., New York) pp. 73-109.
Skoza et al., 1978, "Procedure for Preparation of Liposomes with Large Internal Aqueous Space and High Capture by Reverse-phase Evaporation", Proc. Natl. Acad. Sci. USA 75:4194-4198.
Chen, 1996, Polymerized Liposomes as Potential Oral Vaccine Delivery Vehicles, (Doctoral Thesis, Massachsuettes Institute of Technology).
Chen et al., 1996, "Polymerized Liposomes as Potential Oral Vaccine Carriers: Stability and Bioavailability", J. Controlled Release 42:263-272.
Chen et al., 1996, "Lectin-Bearing Polymerized Liposomes as Potential Oral Vaccine Carriers", Pharm. Res. 13:1378-1383.
Chen et al., 1996, "Surface-Modified Polymerized Liposomes: Novel Vehicles for Oral Vaccination", Proc. 5th World Congress of Chemical Engineering, pp. 824-829.
Ivanoff et al., 1996, "Muscosal Vaccination Against Schistosomiasis Using Liposomes-Associated Sm 28 kDa Glutathiono S-Transferase", Vaccine 14: 1123-1131.
Chen et al., 1995, "Lectin-Bearing Polymerized Liposomes as Potential Oral Vaccine Carriers", Proc. Int. Symp. Controlled Release Bioact. Mater. 22:204-205 (CA: 123(26):350120y).
Chen and Langer, 1995, "Lectin-Bearing Polymerized Liposomes: Novel Vehicles for Oral Vaccine Delivery", Proc. 3rd U.S.-Japan Symposium on Drug Delivery, p. 23.
de Haan et al., 1995, "Mucosal Immunoadjuvant Activity of Liposomes: Induction of Systemic IgG and Secretory IgA Responses in Mice by Intranasal Immunization with an Influenze Subunit Vaccine and Coadministered Liposomes", Vaccine 13:155-162.
Estrada et al., 1995, "Intestinal Immunization of Mice with Antigen Conjugated to Anti-MHC Class II Antibodies", Vaccine 13:901-907.
Kilpatrick, 1996, "Lectins in Immunology", in: Lectins: Biomedical Perspectives, Pusztai and Bardocz, eds., Taylor & Francis, London, England, pp. 155-182.
Ogawa et al., 1995, "Oral Immunoadjuvant Activity of Lipophilic Derivatives of N-acetylglucosaminyl-.beta.(1.fwdarw.4)-N-acetylmuromuyl-L-alanyl-D-isoglu taminyl-(L)-2,6-meso-diaminopimeric acid-(D)-amide", Vaccine 13:887-889.
Okada et al., 1995, "In Vitro Evaluation of Polymerized Liposomes as Oral Drug Delivery System", Pharm. Res. 12:576-582.
Zhou et al., 1995, "Muscoal IgA Response to Rectally Administered Antigen Formulated in IgA-Coated Liposomes", Vaccine 13:637-644.
Allen et al., 1994, "Antibody-Mediated Targeting of Long Circulating (Stealth.RTM.) Liposomes", J. Liposomes Res. 4:1-25.
Anderson et al., 1994, "Cytokines in Liposomes: Preliminary Studies with IL-1, IL-2, IL-6, GM-CSF and Interferon-.gamma.", Cytokine 6:92-101.
Aramaki et al., 1994, "Activation of Systemic and Mucosal Immune Response Following Nasal Administration of Liposomes", Vaccine 12:1241-1245.
Childers and Michalek, 1994, "Liposomes", pp. 241-254, in: Novel Delivery Systems for Oral Vaccines, O'Hagan, ed., CRC Press.
Lehr, 1994, "Bioadhesion Technologies for the Delivery of Peptide and Protein Drugs to the Gastrointestinal Tract", Critical Reviews in Therapeutic Drug Carrier Systems 11:119-160.
Lipford et al., 1994, "Vaccination with Immunodominant Peptdies Encapsulated in Quil-A-Containing Liposomes Induces Peptide-Specific Primary CD8+ Cytotoxic T Cells", Vaccine 12:73-80.
O'Hagan, 1994, "Microparticles as Oral Vaccines", in: Novel Delivery Systems for Oral Vaccines, O'Hagan, ed., CRC Press, Boca Raton, FL, pp. 175-204.
Russel-Jones, 1994, "Oral Vaccination with Lectins and Lectin-Like Molecules", in: Novel Delivery Systems for Oral Vaccines, O'Hagan, ed., CRC Press, Boca Raton, FL, pp. 225-254.
Tanguay et al., 1994, "In Vivo Modulation of Macrophage Tumoricidal Activity by Oral Administration of the Liposome-Encapsulated Macrophage Activator CGP 19835A", Cancer Res. 54:5882-5888.
Aramaki et al., 1993, "Stability of Liposomes In Vitro and Their Uptake by Rat Peyer's Patches Following Oral Administration", Pharm. Res. 10: 1228-1231.
Clarke and Stokes, 1992, "The Intestinal and Serum Humoral Immune Response to Mice to Systemically and Orally Administered Antigens in Liposomes: I. The Response to Liposome-Entrapped Soluble Proteins", Vet. Immunol. Immunopathol. 32:125-138.
Clarke and Stokes, 1992, "The Intestinal and Serum Humoral Immune Response of Mice to Orally Administered Antigens in Liposomes: II. the Response to Liposome-Entrapped Bacterial Proteins", Vet. Immunol. Immunopathol. 32:139-148.
Tsuchida et al., 1992, "Polymerization of Unsaturated Phospholipids as Large Unilamellar Liposomes at Low Temperature", Macromolecules 25:207-212.
Uwiera et al., 1992, "Liposomes Targeted to Deliver Antisecretory Agents to Jejunal Mucosa", Can. J. Vet. Res. 56:249-255.
Childers et al., 1990/1991, "Mucosal and Systemic Responses to an Oral Liposome Streptococcus mutans Carbohydate Vaccine in Humans", Regional Immunol. 3:289-296.
Childers, et al., 1990, "Ultrastructural Study of Liposome Uptake by M Cells of Rat Peyer's Patch: An Oral Vaccine System for Delivery of Purified Antigen", Regional Immunol. 3:8-16.
Eldridge et al., 1990, "Controlled Vaccine Release in the Gut-Associated Lymphoid Tissues. I. Orally Administered Biodegradable Microspheres Target the Peyer's Patches", J. Controlled Release 11:205-214.
Gregoriadis, 1990, "Immunological Adjuvants: A Role for Lipo

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