Polymerized hemoglobin

Details Polymerized hemoglobin Polymerized hemoglobin

1996-10-18

1999-12-07

Richter, Johann

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 6, 530380, 530385, A61K 3514

Patent

active

059983612

ABSTRACT:
Stroma-free hemoglobin intermolecularly cross-linked, i.e., polymerized, so as to transform stroma-free hemoglobin into a physiologically competent oxygen carrier which is retained in vivo for adequate periods of time, and thus can be used in fluids for transporting oxygen is described.

REFERENCES:
patent: 5349054 (1994-09-01), Bonaventura et al.
patent: 5387672 (1995-02-01), Bucci et al.
patent: 5753616 (1998-05-01), Rausch et al.
Grabarek et al, Analytical Biochemistry, 185:131-135 (1990).
Staros et al., "Enhancement of Water-Soluble Carbodiimide-Mediated Coupling Reactions" Anal. Biochem., v. 156, pp. 220-222, 1986.
Acharya et al., "Reactivity of Glu-22(.beta.) of Hemoglobin -S for Amidation with Glucosamine" Biochemistry, v. 24, p. 4885-4890, 1985.
Grabarek, "Zero Length Crosslinking Procedure w/Use of Active Esters" Anal. Biochem., v. 185, pp. 131-135, 1990.

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