Polymerized chiral micelles for chiral separations

Details Polymerized chiral micelles for chiral separations Polymerized chiral micelles for chiral separations

1996-08-15

1998-06-23

Therkorn, Ernest G.

Liquid purification or separation

Processes

Liquid/liquid solvent or colloidal extraction or diffusing...

210634, 210649, 210656, 2101982, 95 88, 204451, B01D 1508

Patent

active

057700842

ABSTRACT:
Chiral separations can be enhanced through the use of polymerized chiral micelles. Because polymerized micelles eliminate much of the complex dynamic behavior associated with conventional micelles, polymerized chiral micelles have stronger chiral recognition properties than do otherwise-identical, "conventional" or non-polymerized chiral micelles. Recovery of chiral ligands from polymerized chiral micelles is often easier, as the chiral ligands may typically be recovered by simple extraction with an appropriate organic solvent. By contrast, recovering the solute from a conventional, non-polymerized micellar medium by extraction with an organic solvent frequently results in the formation of troublesome emulsion systems. Polymerized chiral micelle systems are therefore beneficial in both preparative-scale and process-scale separations. Polymerized chiral micelles have no critical micelle concentration, allowing lower concentrations to be used in micellar electrokinetic capillary chromatography, which in turn reduces the otherwise deleterious heat that can be generated.

REFERENCES:
patent: 4516984 (1985-05-01), Warner
patent: 4688901 (1987-08-01), Albert
D. Armstrong, "Optical Isomer Separation by Liquid Chromatography," Anal. Chem. vol. 59, pp. 84A-91A (1987).
R. J. Baczuk et al., "Liquid Chromatographic Resolution of Racemic .beta.-3,4-Dihydroxyphenylalanine," J. Chromatogr., vol. 60, pp. 351-361 (1971).
E. Gassmann et al., "Electrokinetic Separation of Chiral Compounds," Science, vol. 230, pp. 813-814 (1985).
R. Kuhn et al., "Chiral Separation by Capillary Electrophoresis," Chromatographia, vol. 34, pp. 505-512 (1992).
S. Terabe et al., "Chiral Separation by Electrokinetic Chromatography with Bile Salt Micelles," J. Chromatogr., vol. 480, pp. 403-411 (1989).
S. Terabe et al., "Separation of Enantiomers by Capillary Electrophoretic Techniques," J. Chromatogr. A, vol. 666, pp. 295-319 (1994).
T. Ward, "Chiral Media for Capillary Electrophoresis," Anal. Chem., vol. 66, pp. 632A-640A (1994).
M. Novotny et al., "Chiral Separation through Capillary Electromigration Methods," Anal. Chem., vol. 66, pp. 646A-655A (1994).
S. Terabe et al., "Electrokinetic Chromatography with Micellar Solution and Open-Tubular Capillary," Anal. Chem., vol. 57, pp. 834-841 (1985).
S. Terabe et al., "Electrokinetic Separations with Micellar Solutions and Open-Tubular Capillaries," Anal. Chem., vol. 56, pp. 111-113 (1984).
C. Paleos et al., "Comparative Studies between Monomeric and Polymeric Sodium 10-Undecenoate Micelles," J. Phys. Chem., vol. 87, pp. 251-254 (1983).
D. Tabor et al., "Some Factors in Solute Partitioning between Water and Micelles or Polymeric Micelle Analogues," Chromatogr., vol. 20, pp. 73-80 (1989).
S. Terabe et al., "Ion-Exchange Electrokinetic Chromatography with Polymer Ions for the Separation of Isomeric Ions Having Identical Electrophoretic Mobilities," Anal. Chem., vol. 62, pp. 650-652 (1990).
J. Fendler et al., "Polymerized Surfactant Aggregates: Characterization and Utilization," Acc. Chem. Res., vol. 17, pp. 3-8 (1984).
K. Nagai et al., "Polymerization of Micellized 1-0-3-(4-vinylphenyl)propyl-.beta.-D-glucopyranose," Makromol. Chem., vol. 188, pp. 1095-1127 (1987).
J. Wang and I. Warner, "Chiral Separations Using Micellar Electrokinetic Capillary Chromatography and a Polymerized Chiral Micelle," Anal. Chem., vol. 66, pp. 3773-3776 (Nov. 1, 1994).
J. Wang and I. Warner, "Combined Polymerized Chiral Micelle and .gamma.-Cyclodextrin for Chiral Separation in Capillary Electrophoresis," pp. 1-21 undated.
D. Armstrong et al., "Enrichment of Enantiomers and Other Isomers with Aqueous Liquid Membranes Containing Cyclodextrin Carriers," Anal. Chem., vol. 59, pp. 2237-2241 (1987).
K. Taguchi et al., "Immobilized Bilayer Stationary Phases in Gas Chromatography," J. Chem. Soc., Chem. Commun., pp. 364-365 (1986).
Y. Ishihama et al., "Enantiomeric Separation by Micellar Electrokinetic Chromatography Using Saponins," J. Liq. Chromatogr., vol. 16, pp. 933-944 (1993).
C. Larrabee et al., "Radiation-Induced Polymerization of Sodium 10-Undecenoate in Aqueous Micelle Solutions," J. Poly. Sci.: Poly. Lett. Ed., vol. 17, pp. 749-751 (1979).
C. Palmer et al., "A Monomolecular Pseudostationary Phase for Micellar Electrokinetic Capillary Chromatography," J. High Res. Chromatogr., vol. 15, pp. 756-762 (1992).
K. Otsuka et al., "Enantiomeric Resolution by Micellar Electrokinetic Chromatography with Chiral Surfactants," J. Chromatogr., vol. 515, pp. 221-226 (1990).

Affiliated with

Also associated with

Rating

Polymerized chiral micelles for chiral separations does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polymerized chiral micelles for chiral separations, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polymerized chiral micelles for chiral separations will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1391784