Polymerizable heterocyclic disulfide-based compounds and membran

Details Polymerizable heterocyclic disulfide-based compounds and membran Polymerizable heterocyclic disulfide-based compounds and membran

1986-11-25

1989-02-28

Lovering, Richard D.

Stock material or miscellaneous articles

Coated or structually defined flake, particle, cell, strand,...

Particulate matter

264 43, 264 46, 264 47, 260399, 2604025, 424450, 436829, 549 7, A61K 966, B01J 1302, C07D33902

Patent

active

048084808

ABSTRACT:
Compounds adapted to making polymerizable, cross linkable vesicles and methods for making these compounds comprising combining a phophatidylcholine derivative with an acid anhydride of a heterocyclic carbon/disulfide to form reaction products which when dispersed in aqueous buffer form vesicles that are readily polymerized by the addition of a reducing agent. The reduced vesicles form polymerized, highly cross-linked, vesicles which have a much greater stability and longer shelf life.

REFERENCES:
patent: 4348329 (1982-09-01), Chapman
patent: 4429008 (1984-01-01), Martin et al.
patent: 4485045 (1984-11-01), Regen
patent: 4492659 (1985-01-01), Bosies et al.
patent: 4515736 (1985-05-01), Deamer
patent: 4594193 (1986-06-01), Regen
Regen et al.: "Polymerization of Macrocyclic Phospholipid- and Surfactant-Based Vesicles", J. Am. Chem. Soc., 1985, 107, 5804-5805.

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