Synthetic resins or natural rubbers -- part of the class 520 ser – Synthetic resins – Polymers from only ethylenic monomers or processes of...
Patent
1990-09-04
1992-02-04
Schofer, Joseph L.
Synthetic resins or natural rubbers -- part of the class 520 ser
Synthetic resins
Polymers from only ethylenic monomers or processes of...
5263031, 526328, C08F22022, C08F22238, C08F22010
Patent
active
050861387
DESCRIPTION:
BRIEF SUMMARY
The invention relates to a polymerisable composition and to a polymer produced therefrom. Polymers which are biocompatible and which may be employed in a variety of biomedical applications may be produced from the compositions of the invention.
More particularly, polymers are provided which are capable of immobilizing compounds containing amino groups. Such compounds include proteins and amino acids. Specific applications of the polymers of the invention include affinity chromatography wherein an amino group-containing ligand is attached to the polymer and peptide synthesis.
For example, the polymers of the invention could be used for the separation of a component of a body fluid e.g. blood using a bioaffinity separation procedure. This could be achieved by bringing the body fluid into contact with the polymer having an appropriate protein ligand attached to its surface.
Preferred polymer compositions of the invention are those from which hydrogels may be produced. A hydrogel is a polymeric material that imbibes a significant proportion of water within a three dimensional network without causing dissolution of the polymer.
Die Makromolekulare Chemie 177, 683-689 (1976) describes the synthesis of monomers containing a reactive ester group capable of coupling with an amine by the formation of an amide link. More particularly, it suggests that copolymers of succinimido esters of .omega.-methacryloylaminocarboxylic acid and methacrylamide may be used as carriers for enzymes and drugs.
U.S. Pat. No. 4,330,440 describes an activated polymer matrix for use in affinity chromatography. A macroporous polymer having surface hydroxyl groups e.g. hydroxyethyl methacrylate is treated with a carbonylating agent to provide active groups which are capable of immobilising compounds containing amino groups.
U.S. Pat. No. 4,433,111 describes polymeric materials suitable for biomedical applications, particularly for making contact lenses. The materials have enhanced surface properties which improve their protein repellency. Examples of other biomedical applications which are mentioned in the specification include surgical implants and prosthetic devices e.g. blood vessels, artificial urethers, heart valves and artificial breast tissue. The polymeric materials are also said to be useful for contact with body fluids outside the body e.g. in manufacturing membranes for kidney dialysis and heart/lung machines, swabs, nappy liners and wound dressings.
The hydrogel-forming polymeric material of U.S. Pat. No. 4,433,111 comprises units derived from (1) an olefinically unsaturated carboxylic acid amide, (2) an N-vinyl lactam, (3) an olefinically unsaturated carboxylic acid ester, (4) an olefinically unsaturated carboxylic acid and (5) a hydrophobic monomer comprising (a) a fluorine-containing polymerisable monomer having a fluoroaliphatic side chain and (b) a non-fluorine-containing polymerisable hydrophobic vinyl monomer. The various units are present in specified amounts and the copolymer is cross-linked with a cross-linking agent. The disclosure demonstrates the ability of the fluorine-containing monomer to affect the surface energy of the polymer and increase its protein repellency.
Unlike the polymer compositions of the present invention, the hydrogels according to U.S. Pat. No. 4,433,111 are specifically designed to be unreactive i.e. they do not contain reactive groups for the purpose of reacting with other compounds. While the polymer compositions of U.S. Pat. No. 4,330,440 do contain such reactive groups, the compositions and their preparation have a number of disadvantages. In this respect, the compositions require the provision of a macroporous polymer followed by separate steps to activate the polymer. Further, no action is taken to minimise non-specific adsorption to the polymer i.e. the adsorption of compounds other than those intended to react with the active groups. Similarly, the polymer compositions of Die Makromolekulare Chemie 177, 683-689 (1976) are reactive but make no provision for minimising non-specific adsorpt
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Eastman Kodak Company
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