Polymeric thiol-linked prodrugs

Details Polymeric thiol-linked prodrugs Polymeric thiol-linked prodrugs

2006-04-25

2006-04-25

Campell, Bruce R. (Department: 1654)

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Ion exchange resin

Reexamination Certificate

active

07033583

ABSTRACT:
Thiol-linked polymeric prodrugs and methods of making and using the same are disclosed. The use of a sulfhydryl bond as the basic link for linking the polymer to the drug allows a prodrug to be formed which takes advantage of plasma enzymes in vivo. A preferred conjugate isMethods of preparing and treatment are also disclosed.

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