Polymeric platinum complex, preparation thereof, and anticancer

Details Polymeric platinum complex, preparation thereof, and anticancer Polymeric platinum complex, preparation thereof, and anticancer

1996-01-02

1997-09-09

Kulkosky, Peter F.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Aftertreated polymer

525538, 424649, A61K 31785, A61K 3324

Patent

active

056653433

ABSTRACT:
A novel polymeric platinum complex represented by the following formula (I): ##STR1## wherein, S, A, x, m and n are defined as above, a process for preparation thereof, and the use thereof as an anticancer agent.

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M. J. Cleare, et al. "Anti-tumour platinum complexes", Biochimie 60, 835-850 (1978).
Evan B. Douple, Pharmac. Ther., "CIS-Diamminedichloroplatinum(II): Effects of a Representative Metal Coordination Complex on Mammalian Cells" 25, 297-326 (1984).
Suzanne E. Sherman, et al. Chem. Rev., "Structural Aspects of Platinum Anticancer Drug Interactions with DNA" 87, 1153-1181 (1987).
R. C. Harrison, et al. Inorganica Chimica Act, "An Efficient Route for the Preparation of Highly Soluble Platinum (II) Antitumour Agents" 46, L15-L16 (1980).
H. R. Allcock, et al. Macromolecules "Polymerization of Hexachlorocyclotriphosphazene" 8, No. 1, 36-42 (1975).

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