Polymeric ophthalmic lens with crosslinker containing saccharide

Details Polymeric ophthalmic lens with crosslinker containing saccharide Polymeric ophthalmic lens with crosslinker containing saccharide

1996-09-13

1997-11-25

Mullis, Jeffrey C.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

523108, 523106, 52623823, C08B 3700

Patent

active

056909535

ABSTRACT:
An ophthalmic lens, particularly a soft hydrogel contact lens, is disclosed. The lens can be derived from a crosslinked polymer made by reacting a hydrophilic monomer with a crosslinking amount of a polyfunctional compound containing a saccharide residue. The preferred hydrophilic monomer is actually a mixture of the following individual hydrophilic monomers: a) the reaction product of a free radical reactive monoisocyanate and a monoalkoxy polyalkylether, b) N,N-dimethylacrylamide, and optionally c)hydroxyethyl methacrylate. The preferred polyfunctional compound is a prepolymer derived from an alkoxylated glucose or sucrose. This prepolymer can be made by reacting glucose or sucrose, which has been ethoxylated or propoxylated, with a free radical reactive isocyanate which has been capped. The free radical reactive isocyanate can be capped by reacting it with a polyalkylether, such as polyethylene glycol, and then reacting this intermediate with a diisocyanate.

REFERENCES:
patent: 5034461 (1991-07-01), Lai et al.
patent: 5039769 (1991-08-01), Molock et al.
patent: 5070166 (1991-12-01), Su et al.
patent: 5196458 (1993-03-01), Nunez et al.

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