Polymeric nanofibers for tissue engineering and drug delivery

Stock material or miscellaneous articles – Coated or structually defined flake – particle – cell – strand,... – Rod – strand – filament or fiber

Reexamination Certificate

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C623S023740, C623S011110, C606S222000, C428S036300

Reexamination Certificate

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10938493

ABSTRACT:
Polymeric nanofibers have been developed which are useful in a variety of medical and other applications, such as filtration devices, medical prosthesis, scaffolds for tissue engineering, wound dressings, controlled drug delivery systems, cosmetic skin masks, and protective clothing. These can be formed of any of a variety of different polymers, either non-degradable or degradable. In a preferred embodiment demonstrated in the following examples, nanofibers are formed of biodegradable and non biodegradable polyphosphazenes, their blends with other polyphosphazenes or with organic, inorganic/organometallic polymers as well as composite nanofibers of polyphosphazenes with nanosized particles such as hydroxyapatites.

REFERENCES:
patent: 1975504 (1934-10-01), Formhals
patent: 2160962 (1939-06-01), Formhals
patent: 2187306 (1940-01-01), Formhals
patent: 5053451 (1991-10-01), Allcock et al.
patent: 5629009 (1997-05-01), Laurencin et al.
patent: 5766618 (1998-06-01), Laurencin et al.
patent: 6077916 (2000-06-01), Laurencin et al.
patent: 6093758 (2000-07-01), Allcock et al.
patent: 6392008 (2002-05-01), Allcock et al.
patent: 6605237 (2003-08-01), Allcock et al.
patent: 6685956 (2004-02-01), Chu et al.
patent: 6689166 (2004-02-01), Laurencin et al.
patent: 6737447 (2004-05-01), Smith et al.
patent: 2002/0173213 (2002-11-01), Chu et al.
patent: 2003/0050711 (2003-03-01), Laurencin et al.
patent: WO 01/26702 (2001-04-01), None
patent: WO 0126702 (2001-04-01), None
Allcock, “Developments at the interface of inorganic, organic, and polymer chemistry”Chemical and Engineering News63(11): 22-36 (1985).
Ambrosio, et al., “Degradable polyphosphazene/poly(α-hydroxyester) blends: degradation studies”Biomaterials23: 1667-1672 (2002).
Baumgarten, “Electrostatic spinning of acrylic microfibers”Journal of Colloid and Interface Science36(1): 71-79 (1971).
Bognitzki, et al., “Nanostructured fibers via electrospinning”Advanced Materials13: 70-72 (2001).
Buchko, et al., “Processing and microstructural characterization of porous biocompatible protein polymer thin films”Polymer40: 7397-7407 (1999).
Dayton, et al., “Use of an absorbable mesh to repair contaminated abdominal-wall defects”Arch. Surgery121(8): 954-960 (1986).
Huang, et al., “Engineered collagen-PEO nanofibers and fabrics”J Biomater Sci Polym Edn.12(9): 979-993 (2001).
Huang, et al., “A review on polymer nanofibers by electrospinning and their applications in nanocomposites”Composites Science and Technology63: 2223-2253 (2003).
Ibim, et al., “Novel polyphosphazene/poly(lactide-co-glycolide) blends: miscibility and degradation studies”Biomaterials18: 1565-1569 (1997).
Kenawy, et al., “Antimicrobial properties of modified and electrospun poly(vinyl phenol)”Macromoleuclar Bioscience2: 261-266 (2002).
Klinge, et al., “Functional assessment and tissue response of short- and long-term absorbable surgical meshes”Biomaterials22: 1415-1424 (2001).
Krishnappa, et al., “Electrospinning of polycarbonates and their surface characterization using the SEM and TEM”Mat Res Soc Symp Proc702: U6.7.1-U 6.7.6 (2002).
Laurencin, et al., “Use of polyphosphazenes for skeletal tissue regeneration”J. Biomed. Mater. Res.27: 963-973 (1993).
Laurencin, et al., “A highly porous 3-dimensional polyphosphazene polymer matrix for skeletal tissue regeneration”J. Biomed. Mater. Res.30: 133-138 (1996).
Li, et al., “Electrospun nanofibrous structure: A novel scaffold for tissue engineering”J Biomed Mater Res60: 613-621 (2002).
MacDiarmid, et al., “Electrostatically-generated nanofibers of electronic polymers”Synthetic Metals, 119: 27-30 (2001).
Megelski, et al., “Micro- and nanostructured surface morphology on electrospun polymer fibers”Macromolecules35: 8456-8466 (2002).
Reneker and Chun, “Nanometre diameter fibres of polymer, produced by electrospinning”Nanotechnology7(3): 216-223 (1996).
Schreuder-Gibson, et al., “Protective textile materials based on electrospun nanofibers”J. Adv. Mater.34: 44-55 (2002).
Senador et al., “Electrospinning of polymeric nanofibers: Analysis of jet formation”Mat. Res. Soc. Symp. Proc.661: KK5.9.1-KK5.9.6 (2001).
Tsai ,et al., “Different electrostatic methods for making electret filters”J. Electrostatics54: 333-341 (2002).
Wang, et al., “Electrospun nanofibrous membranes for highly sensitive optical sensors”Nano Letters2(11): 1273-1275 (2002).
Yashimoto, et al., “A biodegradable nanofiber scaffold by electrospinning and its potential for bone tissue engineering”Biomaterials24: 2077-2082 (2003).
Zong, et al. “Structure and process relationship of electrospun bioabsorbable nanofiber membranes”Polymer43: 4403-4412 (2002).

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