Polymeric microporous film coated subcutaneous implant

Details Polymeric microporous film coated subcutaneous implant Polymeric microporous film coated subcutaneous implant

1997-12-15

2000-02-08

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424422, 424424, 424425, 424433, 424438, 424468, 424472, 424476, 424484, 424487, 424494, 424498, 530399, A61F 200, A61F 210

Patent

active

060225548

ABSTRACT:
This invention relates to coating formulations for coating sustained-release drug implants. The coating formulations are capable of formulations are capable of forming a porous film coat over a biologically active agent to provide a release of the active agent at a constant rate over a prolonged period of time. The pore forming agent is used in the formulation of the invention in the amount effective to regulate the release of a biologically active compound at a desired rate. Preferably, the effective amount of the pore forming agent provides long term delivery of the active agent. The invention also provides an improved implant for the sustained administration of a biologically active compound suitable for subcutaneous implantation. The invention also relates to methods for making and using the formulation and the implant of the invention.

REFERENCES:
patent: 3948254 (1976-04-01), Zaffaroni
patent: 3992518 (1976-11-01), Chien et al.
patent: 4096239 (1978-06-01), Katz et al.
patent: 4180560 (1979-12-01), Katz et al.
patent: 4200098 (1980-04-01), Ayer et al.
patent: 4315925 (1982-02-01), Hussain et al.
patent: 4333919 (1982-06-01), Kleber et al.
patent: 4472394 (1984-09-01), Peterson
patent: 4666704 (1987-05-01), Shalati et al.
patent: 4758435 (1988-07-01), Schaaf
patent: 5035891 (1991-07-01), Runkel et al.
patent: 5091185 (1992-02-01), Castillo et al.
patent: 5342622 (1994-08-01), Williams et al.
patent: 5595762 (1997-01-01), Derrieu et al.
patent: 5618553 (1997-04-01), Kelleher
International Search Report.
Herschler, R.C. et al., J. Anim. Sci., 73:2873-2881, 1995.
Hsieh, Dean S.T. et al., Drug Development and Industrial Pharmacy, 13(15):2651-2666, 1987.
Istasse, L. et al., J. Anim. Sci., 66:1212-1222, 1988.
Ferguson, TH et al., J. Controlled Release, 8:45-54, 1988.
Ozturnk, A.G. et al., J. Controlled Release, 14:203-213, 1990.
Zhang, X. et al., J. Controlled Release, 29:157-161, 1994.
Deasy, P.B. et al., International J. of Pharmaceutics, 89:251-259, 1993.
Munday, D.L. et al., International J. of Pharmaceutics, 52:109-114, 1989.
Muhammad, N.A. et al., Drug Development and Industrial Pharmacy, 17(18):2497-2509, 1991.
Marini, J.O. et al., Drug Development and Industrial Pharmacy, 17(6):865-877, 1991.
Donbrow, M. et al., J. Pharm. Pharmacol., 32:463-470, 1980.
Fed. Regist. (1996), 61(64), 14482, Apr. 2, 1996.
Fed. Regist. (1996) 61(113), 29479-29480, Jun. 11, 1996.
Fed. Regist. (1996), 61(155), 41498-41499, Aug. 9, 1996.
Fed. Regist. (1995), 60(14), 4375-6, Jan. 23, 1995.
Fed. Regist. (1994), 59(189), 49807-8, Sep. 30, 1994.
Zentner, G.M. et al., J. Pharm. Sci., 68(6):794-5, Jun. 1979.
Deasy, P.B. et al., Proceed. Intern. Symp. Control. Rel. Bioactive Materials, 20:163-164, 1993.
Coward, P. et al., J. Virology,66(1):286-295, Jan. 1992.

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