Surgery – Truss – Pad
Patent
1994-08-18
1996-10-08
Kulkosky, Peter F.
Surgery
Truss
Pad
A61K 4900, A61K 5112
Patent
active
055620990
ABSTRACT:
Compositions, methods for preparing and methods of using contrast agent-filled polymeric microparticles for imaging are disclosed. In a preferred embodiment, air-encapsulating microparticles are formed by ionotropically gelling synthetic polyelectrolytes such as poly(carboxylatophenoxy)phosphazene, poly(acrylic acid), poly(methacrylic acid) and methacrylic acid copolymers (Eudragit's) by contact with multivalent ions such as calcium ions. In the preferred embodiment, the average size of the microparticles is less than seven .mu.m so that they are suitable for injection intravenously. The polymeric microparticles are stable to imaging and display high echogenicity, both in vitro and in vivo. Due to their in vivo stability their potential application is extended beyond vascular imaging to liver and renal diseases, fallopian tube diseases, detecting and characterizing tumor masses and tissues, and measuring peripheral blood velocity. The microparticles can optionally be linked with ligands that minimize tissue adhesion or that target the microparticles to specific regions.
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Allcock Harry R.
Andrianov Alexander K.
Cohen Smadar
Langer Robert S.
Wheatley Margaret
Kulkosky Peter F.
Massachusetts Institute of Technology
The Penn State Research Foundation
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