Polymeric micelle containing cisplatin enclosed therein and...

Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Aftertreated polymer

Reexamination Certificate

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Details

C424S078080, C424S489000, C424S604000, C514S492000, C514S772600

Reexamination Certificate

active

07125546

ABSTRACT:
Provided is a complex comprising cisplatin encapsulated therein in a form in which a chlorine ion thereof is ligand-exchanged with a carboxyl anion of a block copolymer comprising poly(ethylene glycol)-poly(glutamic acid). This complex can be a medicinal preparation to which a novel dosage form decreased in toxicity can be applied.

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B. Schechter et al., “Increased Therapeutic Efficacy of Cis-Platinum Complexes of Poly-L-Glutamic Acid Against A Murine Carcinoma”, International Journal of Cancer, vol. 39, No. 3, pp. 409-413, 1987.
S. R. Meshnick et al., “Capacity of a Cis-Diammineplatium [II]-Poluglutamic Acid Complex to Cure Trypanosoma Congolense Infections in Mice”, vol. 25, No. 2, pp. 286-288, Feb. 1984.
M. Yokoyama et al., “Introduction of cisplatin into polymeric micelle”, Journal of Controlled Release, vol. 39, pp. 351-356, 1996.
N. Nishiyama et al., “Preparation and Characterization of Self-Assembled Polymer-Metal Complex Micelle from cis-Dichlordiammineplatinum(II) and Poly(ethylene glycol)-Poly(α,β-aspartic acid) Block Polymer in an Aqueous Medium”, Langmuir, vol. 15, No. 2, pp. 377-383, 1999.
K. Kataoka, “Nanoparticle formulation from polymeric micelles”, Pharm Tech Japan, vol. 16, No. 8, 2000, pp. 1209-1219 and its partial English translation.

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