Polymeric iron chelators

Details Polymeric iron chelators Polymeric iron chelators

1984-07-20

1986-09-23

Kight, John

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ester doai

514563, 514645, 514815, 514836, 2605005H, 210688, 210692, 210912, 210927, C07C 8104, C02F 142, G21F 904, B01D 1504

Patent

active

046136169

ABSTRACT:
The present invention relates to polymeric iron chelators based upon hydroxamic acids having the general formula: ##STR1## wherein R is hydrogen or lower alkyl. The present compound is useful for the treatment of iron overload disorders particularly arising from iron poisoning and the disease .beta.-thalassemia otherwise known as Cooley's Anemia. The polymeric hydroxamic acids of the present invention exhibit high selectivity for iron, good water solubility for both the chelator and its iron complex, low toxicity and, most significantly, increased bioactivity, i.e., the ability to remove iron in vivo.

REFERENCES:
patent: 3154499 (1964-10-01), Fetscher
patent: 3345344 (1967-10-01), Fetscher et al.
patent: 4256765 (1981-03-01), Munakata et al.
CA 99:169056c, vol. 99, 1983, Winston et al.

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