Polymeric immunological adjuvants

Details Polymeric immunological adjuvants Polymeric immunological adjuvants

1991-10-30

1994-05-17

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

514885, 424 7837, 424450, 436 71, 436547, A61K 31765, A61K 4500, A61K 3720

Patent

active

053126203

ABSTRACT:
Adjuvants for enhancing the immune response to an antigen are provided comprising the adjuvant incorporated into a lipid layer where the adjuvant is covalently or non-covalently involved in a polymeric system. Conveniently, the adjuvant may be conjugated to a polymerizable group and co-polymerized with a water-soluble and/or amphiphilic polymerizable monomer or combined with a polymerized amphiphile. The adjuvant and antigen may then be administered to a mammalian host to obtain enhanced immune response.

REFERENCES:
L. Gros et al Angew. Chemie. Int. Ed. 20, pp. 305-325 (1981).
Cancer Research 40, pp. 2263-2267 Jul. 1980 Hirono et al.
J.A.C.S. Elbert et al. 1985, 107,4134-4141.
Lochensky et al-Macro. Chemie-Abstract Apr. 1986.
Khorlin et al Bioorgan. Khimiya (5) 671-673 May 1985.
Gregoriadia, G. et al.; Vaccine, 5(2): 124-151 (Jun. 1987). Title: Liposoomes as immunilogical adjuvants: antigen incorporation studies.

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