Polymeric-hydroxyapatite bone composite

Details Polymeric-hydroxyapatite bone composite Polymeric-hydroxyapatite bone composite

1994-04-01

1997-05-06

Azpuru, Carlos

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424501, A61F 202, A61K 950

Patent

active

056268610

ABSTRACT:
A method for the fabrication of three-dimensional macroporous polymer matrices for use as bone graft or implant material was developed. The composites are formed from a mixture of biodegradable, biocompatible polymer and hydroxyapatite (HA), a particulate calcium phosphate ceramic. The method leaves irregular pores in the composite between 100 and 250 microns in size. In a preferred embodiment, implants are composed of a 50:50 poly(lactide-co-glycolide) (PLGA) polymer and reinforced by hydroxyapatite. Mechanical and histological analysis showed the matrix fabricated by this method to be structurally and mechanically similar to cancellous bone. Prior to degradation, pure polymer specimens exhibited an elastic modulus of 293 MPa and specimens which were 50% HA by weight exhibited a modulus of 1459 MPa. After six weeks of degradation under physiological conditions, the reinforcing effect of ceramic loading had diminished. Modulus of polymer matrices at all HA load levels had decreased sharply to approximately 10 MPa. Mean macro- and micropore diameters of the polymer specimens were 100 .mu.m and 20 .mu.m respectively and remained constant throughout degradation.

REFERENCES:
patent: 4279249 (1981-07-01), Vert et al.
patent: 4832686 (1989-05-01), Anderson
patent: 5120340 (1992-06-01), Ducheyne
patent: 5236458 (1993-08-01), Ducheyne
patent: 5385887 (1995-01-01), Yim et al.
Aspenberg, P., et al. "Bone morphogenetic protein induces bone in the squirrel monkey, but bone matrix does not" Thirty Ninth Annual Meeting, Orthopaedic Research Society 18, 101 (1993).
Ballock, T.T.,et al, "Regulation of collagen expression in periosteal cells by three members of the TGF-B superfamily" Thirty Ninth Annual Meeting, Orthopaedic Research Society; 18,734 (1993).
Cohen-Solal, et al., "Identification of organic phosphorus covalently bound to collagen and non-collagenous proteins of chicken-bone matrix: the presence of O-phosphoserine and O-phosphothreonine in non-collagenous proteins, and their absence from phosphorylated collagen" Biochem. J. 177:81-98 (1979).
Cook, S.D. et al. "Restoration of large diaphyseal segmental defects in rabbits using recombinant human osteogenic protein (OP-1)" Combined meetings of Orthopaedic Research societies of USA, Japan and Canada 1, 66 (1991).
Cook, S.D., et al. "Recombinant human osteogenic protein-1 (rhOP-1) heals segmental long-bone defects in non-human primates" Thirty Ninth Annual Meeting, Orthopaedic Research Society 18, 484 (1993).
Coombes, A.D.A. and J.D. Heckman, "Gel Casting of Resorbable Polymers: Processing and Applications," Biomaterials, 13(4), 217-224 (1992).
Costantino, et al., "Hydroxyapatite Cement," Arch. Otolaryngol. Head Neck Surg. 117(4), 379-384 (Apr. 1991).
Cytokines and Bone Metabolism, Gowen ed (CRC press, 1992)*.
Frame, J.W., "Hydroxyapatite as a biomaterial for alveolar ridge augmentation," Int. J. Oral Maxillofacial Surgery, 16, 642-55 (1987).
Friedlaender, G.E., "Current Concepts Review; Bone Grafts" Journal of Bone and Joint Surgery, 69A(5), 786-790 (1987).
Friedman, et al., "Hydroxyapatite Cement," Arch. Otolaryngol, Head Neck Surg. 117(4), 386-389 (Apr. 1991).
Gibson, "The Mechanical Behavior of Cancellous Bone" J. Biomechan. 18(5), 317-328 (1985).
Glowacki, et al., "Demineralized Bone Implants," Clin. Plast. Surg. 12(2), 233-241 (1985).
Glowacki, J., et al. "A role of osteocalcin in osteocalast differentiation" J. Cellular Biochem. 45:292-302 (1991).
Harada, "Hydroxyapatite (HAP) Tricalcium Phosphate," Shikwa-Gakuho 89(2), 263-297 (1989).
Hollinger, J.O. and G.C. Battistone, "Biodegradable Bone Repair Materials," Clinical Orthopedics and Related Research, 207, 290-305 (1986).
Hollinger, Jeffrey O., "Preliminary report on the osteogenic potential of a biodegradable copolymer of polyactide (PLA) and polyglycolide (PGA)," J. of Biomedical Mater. Res. 17:71-82 (1983).
Hunt, T.R., et al. "Healing of a segmental defect in the rat femur using a bone inducing agent (BIA) derived from a cultured human osteosarcoma cell line (SAOS-2)" Thirty Ninth Annual Meeting, Orthopaedic Society 18, 489 (1993).
Iwasaki, M., et al. "Bone morphogenetic protein-2 stimulates osteogenesis in high density culture of periosteum-derived cells" Thirty Ninth Annual Meeting, Orthopaedic Research Society 18, 483 (1993).
Jarcho, "Calcium Phosphate Ceramics as Hard Tissue Prosthetics" Clin. Orthopedics and Related Research 157:259-278 1981.
Keaveny, T.M. and W.C. Hayes, "Mechanical Properties of Cortical and Trabecular Bone," in Bone vol. 7: Bone Growth-B, B.K. Hall, ed., Boca Raton: CRC Press, 285-344 (1992).
Kulkarni, et al., "Biodegradable Poly(lactic acid) Polymers," J. Biomedical Materials Research, 5, 169-81 (1971).
Marden,. Leslie J., et al., "Growth and Differentiation Factors: Role in Bone Induction and Potential Application in Craniofacial Surgery," J. Cariofac. Surg. 1(3), 154-160 (Jul. 1990).
Mikos, et al. Biomaterials (1992)*.
Miyamoto, S., et al. "Trans-filter bone induction in monkeys by bone morphogenetic protein" Thirty Ninth Annual Meeting Orthopaedic Research Society 18, 99 (1993).
Ohgushi, et al., "Repair of bone defects with marrow cells and porous ceramic," Acta Orthop. Scand. 60(3), 334-339 (1989).
Ono, et al., "Quantitative study on osteoconduction of apatite-wollastonite containing glass ceramice granules, hydroxyapatite granules, and alumina granules," Biomaterials 11(4), 265-271 (May 1990).
Osol, Arthus (editor), Remington's Pharmaceutical Sciences, Easton: Mack Publishing, 310-17, 1246-51, 1453-4 (1980).
Parsons, et al. "Osteoconductive Composite Grouts for Orthopedic Use," Annals N.Y. Academy of Sciences, 523, 190-207 (1988).
Passuti, et al., "Macroporous Calcium Phosphate Ceramic Performance in Human Spine Fusion," Clin. Orthop. 248, 169-176 (Nov. 1989).
Pinholt, et al., "Alveolar ridge augmentation in rats by Bio-Oss," Scand. J. Dent. Res. 99(2), 154-161 (Apr. 1991).
Pinholt, et al., "Chemical, Physical, and Histologic Studies on Four Commerical Apatites Used for Alveolar Ridge Augmentation," J. Oral Maxillofac. Surg. 50(8), 859-867 (Aug. 1992).
Pochon, et al., "Knochenersatzplastiken mit Beta-Tricalciumphosphat-Resultate experimenteller Studien und erste klinische Fallbeispiele," Z-Kinderchir. 41(3), 171-173 (1986).
Ripamonti, U., et al. "Growth and morphogenetic factors in bone induction: role of osteogenin and related bone morphogenetic proteins" CRC Critical Reviews in Oral Biol. Med. 3:1-14 (1992).
Ripamonti, U., et al, "Induction of bone in composites of osteogenin and porous hydroxyapatite in baboons" J. Plastic and Reconstructive Surg. 89:731-739 (1991).
Ripamonti, U., et al. "Xenogeneic osteogenin and demineralized bone matrices including human induced bone differentiation in athymic rats and baboons" Matrix 11:404-411 (1991).
Ripamonti, U., et al. "Initiation of bone regeneration in baboons by osteogenin, a bone morphogenetic protein" Matrix: 12:40-55 (1992).
Roesgen, Unfallchirurgle 16(5), 258-265 (Oct. 1990)*.
Roesler, H., "The History of Some Fundamental Concepts in Bone Biomechanics," Journal of Biomechanics, 20, 1025-34 (1987).
Yasko, A.W., et al. "Comparison of recombinant human BMP-2 versus cancellous bone to heal segmental bone defects" Thirty Ninth Annual Meeting, Orthopaedic Research Society 18, 100 (1993).

Affiliated with

Also associated with

Rating

Polymeric-hydroxyapatite bone composite does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polymeric-hydroxyapatite bone composite, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polymeric-hydroxyapatite bone composite will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2130555