Drug – bio-affecting and body treating compositions – Designated organic nonactive ingredient containing other... – Aftertreated solid synthetic organic polymer
Patent
1995-07-28
1999-03-02
Nutter, Nathan M.
Drug, bio-affecting and body treating compositions
Designated organic nonactive ingredient containing other...
Aftertreated solid synthetic organic polymer
5147723, 5147724, 5147725, 5147726, 424484, 424485, 424486, 424487, 424488, 424 7831, 524 27, A61K 4730, A61K 4732, A61K 4734, A61K 914
Patent
active
058772243
ABSTRACT:
Polymeric drug formulations containing a non-releasing single-phase dispersion of a water-soluble drug in a water-insoluble tissue-compatible polymer matrix. Polymeric drug formulations are also disclosed containing a single-phase dispersion of a water-soluble drug and a water-insoluble tissue-compatible polymer matrix, and a second, phase-disrupting polymer that is non-miscible with the tissue-compatible polymer and is present in an amount sufficient to form phase-separated microdomains of the second polymer in the tissue-compatible polymer matrix, so that the release rate of the water-soluble drug from the tissue-compatible polymer matrix is related to the amount of the second polymer. Methods of preparing the polymeric drug formulations are also described, as well as methods for site-specific drug delivery utilizing the polymeric drug formulations.
REFERENCES:
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patent: 5219564 (1993-06-01), Zalipsky et al.
patent: 5330768 (1994-07-01), Park et al.
Sturesson et al., International Journal of Pharmaceutics, 89, 235-244 (1993).
Brocchini Stephen
Hanson Stephen R.
Kohn Joachim B.
Nutter Nathan M.
Rutgers The State University of New Jersey
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