Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...
Patent
1982-09-28
1984-09-18
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Identification or warning feature
Taste or smell or chemical irritation to the eye, nose, or...
424 22, 424 28, 424 78, 424 80, A61L 1503, A61F 1300, A61K 970
Patent
active
044723725
ABSTRACT:
There is disclosed a polymeric diffusion matrix for the sustained release of chlorpheniramine maleate by transdermal delivery to a patient wherein the matrix comprises a polar plasticizer, polyvinylalcohol, polyvinylpyrrolidone, and a pharmaceutically effective amount of chlorpheniramine maleate.
REFERENCES:
The Pharmacological Basis of Therapeutics, L. S. Goodman and A. Gilman, pp. 603-610, (1975).
Kamishita et al., Chem. Abstr. 85, #254116 (1976) of Japan, Kokai 76 44618, Apr. 16, 1976.
Stephenson et al., Chem. Abstr. 46, #11449 & (1952) Local Anesthetic Potency of Twenty Antihistamines in Guinea Pigs by the Intralutaneous Wheal Method.
Steffen et al., CA. 53, #15348e (1959), Evaluation of Various Antihistamines as Local Anesthetic Agents.
Kushima et al., CA. 62, #12977e, (1965), Lidocaine in Hydrophalic Ointment Conte Chlorpheniramine Maleate.
Hattori et al., CA. 21, #78963, (1979), Dexamethasone and Chlorpheniramine Maleate in Ointment.
Keith Alec D.
Snipes Wallace
Key Pharmaceuticals, Inc.
Rose Shep K.
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