Polymeric diffusion matrix

Details Polymeric diffusion matrix Polymeric diffusion matrix

1981-04-28

1984-09-11

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424 14, 424 16, 424 19, 424 22, 424 78, 424 80, A61L 1503, A61F 1300, A61K 970, A61K 4700

Patent

active

044709625

ABSTRACT:
A polymeric diffusion matrix is provided comprising from about 2 to about 60% glycerol, from about 2 to about 15% polyvinylalcohol, from about 2 to about 10% water soluble polymer with hydration sites which in combination with the remaining ingredients yields a matrix capable of sustained release of a drug dispersed therein, and the balance water, the percentages being by weight.

REFERENCES:
patent: 1280149 (1918-10-01), Breck
patent: 2127896 (1938-10-01), Vohrer
patent: 2138751 (1938-11-01), Vohrer
patent: 2155658 (1939-04-01), Herrmann et al.
patent: 2160503 (1939-05-01), Herrmann
patent: 2340866 (1944-02-01), Dangelmajer
patent: 2491642 (1949-12-01), Brant
patent: 2693438 (1954-11-01), Ward
patent: 2698822 (1955-01-01), Halpern et al.
patent: 2726982 (1955-12-01), Ochs
patent: 2830370 (1958-04-01), Rothrock
patent: 3214338 (1965-10-01), Ehrlich
patent: 3249109 (1966-05-01), Maeth
patent: 3287222 (1966-11-01), Carde et al.
patent: 3339546 (1967-09-01), Chen
patent: 3426754 (1969-02-01), Bierenbaum
patent: 3429308 (1969-02-01), Russell
patent: 3444858 (1969-05-01), Russell
patent: 3520949 (1970-07-01), Shepherd
patent: 3608070 (1971-09-01), Novvel
patent: 3627871 (1971-12-01), Groves et al.
patent: 3729996 (1966-10-01), Long
patent: 3789119 (1974-01-01), Fusari et al.
patent: 3803300 (1974-04-01), Pospischil
patent: 3892905 (1975-07-01), Albert
patent: 3972995 (1976-08-01), Tsuk et al.
patent: 4059686 (1977-11-01), Tanaka et al.
patent: 4091091 (1978-05-01), Terrill
patent: 4210633 (1980-07-01), Takruki et al.
patent: 4226848 (1980-10-01), Nagai et al.
patent: 4291015 (1981-09-01), Keith et al.
patent: 4292299 (1981-09-01), Suzuki et al.
patent: 4292301 (1981-09-01), Keith et al.
Fung et al., J. Pharm. Sci., 63(11):1810-1811, Nov. 1974, Development of a Stable Sublinear Nitroglycerin Tablet I: Interaction of Nitroglycerin with Selected Macromolecules PVP.
Vishnevski, A. A. et al., U.S.S.R. 219116, Mar. 20, 1973, from Otkrytiya, Izobret. Prom. Obraztsy, Tovarny Znaki, 1973, 50(15), 170.
Chem. Abstracts, vol. 79, No. 8, Aug. 27, 1973, #45845b, p. 215, col. 2, U.S.S.R. 219116, Mar. 20, 1973, A. A. Vishnevski et al., Protective and Medicated Film for the Initial Treatment of Scalds.
Ward et al., Amer. Perf. & Cosmetics, 79:53-55, Nov. 1964, The Use of Polyvinyl Alcohol in Film-Forming Bases.
Ward et al., J. Soc. Cos. Chem., 15:327-335, (1964), Cosmetic Applications of Polyvinyl Alcohol.
Toydshima, K., "Compatibility of Polyvinyl Alcohol with Other Water-Soluble High Polymers", in Finch et al., ED, (1967), Polyvinyl Alcohol: Properties & Applications, 535-553.
Ban et al., Pharmazie, 29H9:597-602, (1974), (PVP-PVA).
Nagy et al., "Formation of Disperse Structures in Polymer Gels", Proc. Int. Conf. Colloid & Surface Science, Budapest, Hungary, Sep. 1975, Wolfram Ed., pp. 447-453.
Peierls, Modern Plastics, 18:53-56, Feb. 1941, Polyvinyl Alcohol Plastics.
Hess et al., Rubber Age, 53:431-433, Aug. 1973, Molding Polyvinyl Alcohol.
Ita et al., Bulletin Pharm. Research Inst., Osaka Medical College, (2), 1-3, (1951), II, "On a New Water-Soluble Ointment".
Hirai, Bull. Inst. Chem., Koyoto Univ., 33:21-37, (1955), The Gel-Elasticity of High Polymers.
Langhammer et al., Naturwissen Schaften, 43:125-126, (1956), (PVP-PVA).
(PVP-PVA), Nehring Plaste und Kautschuk, 3:279-280, (1956).
Windholz et al., The Merck Index, 9th Ed., (1976), Merck & Co., Rahway, NJ, p. 471, Entry 3534, Ephedrine, .alpha.[1-(Methylamino)Ethyl]Benzene-Methanol, (Bronchodilator).
Riegelman, Clinical Pharmacology & Therapeutics, 16, (Apr. 5, 1912), 873-883, (1974), Pharmacokinetic Factors Affecting Epidermal Penetration and Percutaneous Absorption.
Graybiel et al., Aviation Space & Environmental Medicine, 52:337-339, (1981), "Efficacy of Transdermal . . . Ephedrine".
Graybiel et al., Aviation Space & Environmental Medicine, 47(10):1096-1100, (1976).
Shaw et al., 14 Controlled Transdermal Delivery in vitro and in vivo, pp. 138-146, Animal Models in Dermatology.
Beckett et al., Pharm. Pharmac., 1972, 24 Suppl., 65 P-70 P, Comparison of Oral and Percotanedes Routes in Man for the Systemic Administration of "Ephedrines".
Gross I: Gross et al., Archiv f/u/ r Tokikologie, vol. 18, 194-199, (1960).
Gross II: Gross et al., Archiv f/u/ r Tokikologie, vol. 18, 331-334, (1960).
PDR: Physician's Desk Reference, Entry for "Nitrol(R) Ointment", 675, (1958).
Davis: Davis et al., Am. Jour. Medical Sciences, 259-263, (Sep. 1955).
Lund: Acta Med. Scand., Suppl. 206; 196-206, (Jun. 1948).
Roseman: Roseman et al., Jour. Pharm. Sci., vol. 59, pp. 353-357, (Mar. 1970).
Kincl: Kincl et al., Steroids, vol. 11, pp. 673-680, (May 1968).

Affiliated with

Also associated with

Rating

Polymeric diffusion matrix does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Polymeric diffusion matrix, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Polymeric diffusion matrix will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1194306